NDLI: In Vitro Screening of Medicinal Plants Used in Mexico as Antidiabetics with Glucosidase and Lipase Inhibitory Activities

Content Provider	PubMed Central
Author	Ramírez, Guillermo Zavala, Miguel Pérez, Julia Alejandro, Zamilpa
Copyright Year	2012
Abstract	This work shows the inhibitory effect on glucosidase and lipase enzymes of 23 medicinal plants described as traditional treatments for diabetes in several Mexican sources. Hydroalcoholic extracts of selected plants were evaluated at 1 mg/mL for glucosidase and 0.25 mg/mL for lipase inhibitory activities, respectively. Camellia sinensis, acarbose, and orlistat were used as positive controls. Dose-response curves were done with the most active species. Sixty percent of all tested extracts inhibited more than 25% of α -glucosidase activity. C. sinensis displayed an inhibition of 85% (IC50 = 299 μ g/mL), while Ludwigia octovalvis and Iostephane heterophylla showed the highest inhibition (82.7 %, IC50 = 202 μ g/mL and 60.6%, CI50 = 509 μ g/mL, resp.). With respect to lipase activity, L. octovalvis and Tecoma stans were the most inhibiting treatments (31.4%, IC50 = 288 μ g/mL; 27.2%, IC50 = 320 μ g/mL), while C. sinensis displayed 45% inhibition (IC50 = 310 μ g/mL). These results indicate that a high proportion of plants used in Mexico as treatment for diabetes displays significant inhibition of these digestive enzymes.
Related Links	http://dx.doi.org/10.1155/2012/701261
Starting Page	701261
File Format	PDF
ISSN	1741427X
e-ISSN	17414288
Journal	Evidence-based Complementary and Alternative Medicine : eCAM
Volume Number	2012
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2012-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Complementary and alternative medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Complementary and Alternative Medicine

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