NDLI: Spike timing plays a key role in synapse elimination at the neuromuscular junction

Content Provider	PubMed Central
Author	Favero, Morgana Giuseppe, Busetto Cangiano, Alberto
Abstract	Nerve impulse activity produces both developmental and adult plastic changes in neural networks. For development, however, its precise role and the mechanisms involved remain elusive. Using the classic model of synapse competition and elimination at newly formed neuromuscular junctions, we asked whether spike timing is the instructive signal at inputs competing for synaptic space. Using a rat strain whose soleus muscle is innervated by two nerves, we chronically evoked different temporal spike patterns in the two nerves during synapse formation in the adult. We found that asynchronous activity imposed upon the two nerves promotes synapse elimination, provided that their relative spikes are separated by 25 ms or more; remarkably, this elimination occurs even though an equal number of spikes were evoked in the competing axons. On the other hand, when spikes are separated by 20 ms or less, activity is perceived as synchronous, and elimination is prevented. Thus, in development, as in adult plasticity, precise spike timing plays an instructive role in synaptic modification.
Related Links	http://dx.doi.org/10.1073/pnas.1201147109
Starting Page	1667
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-06-19
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Spike timing plays a key role in synapse elimination at the neuromuscular junction.

Loss of Glial Neurofascin155 Delays Developmental Synapse Elimination at the Neuromuscular Junction

The Timing of Activity Is a Regulatory Signal During Development of Neural Connections

Data from: The extracellular and cytoplasmic domains of Syndecan cooperate postsynaptically to promote synapse growth at the Drosophila neuromuscular junction (Dataset)

Membrane Receptor-Induced Changes of the Protein Kinases A and C Activity May Play a Leading Role in Promoting Developmental Synapse Elimination at the Neuromuscular Junction

Robustness in locomotory output from synapse-to-synapse diversity in transmission and regulation at the Drosophila larval neuromuscular junction

PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development

Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions.

Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction

Spike timing plays a key role in synapse elimination at the neuromuscular junction

Similar Documents

Spike timing plays a key role in synapse elimination at the neuromuscular junction.

Loss of Glial Neurofascin155 Delays Developmental Synapse Elimination at the Neuromuscular Junction

The Timing of Activity Is a Regulatory Signal During Development of Neural Connections

Data from: The extracellular and cytoplasmic domains of Syndecan cooperate postsynaptically to promote synapse growth at the Drosophila neuromuscular junction (Dataset)

Membrane Receptor-Induced Changes of the Protein Kinases A and C Activity May Play a Leading Role in Promoting Developmental Synapse Elimination at the Neuromuscular Junction

Robustness in locomotory output from synapse-to-synapse diversity in transmission and regulation at the Drosophila larval neuromuscular junction

PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development

Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions.

Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction

Spike timing plays a key role in synapse elimination at the neuromuscular junction