NDLI: Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model

Content Provider	PubMed Central
Author	Jin, Cong Liang, Mifang Ning, Junyu Gu, Wen Jiang, Hong Wu, Wei Zhang, Fushun Li, Chuan Zhang, Quanfu Zhu, Hua Chen, Ting Han, Ying Zhang, Weilun Zhang, Shuo Wang, Qin Sun, Lina Liu, Qinzhi Li, Jiandong Wang, Tao Wei, Qiang Wang, Shiwen Deng, Ying Qin, Chuan Li, Dexin
Abstract	The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis of SFTSV. We are unique in establishing an infectious model of SFTS in C57/BL6 mice, resulting in hallmark symptoms of thrombocytopenia and leukocytopenia. Viral RNA and histopathological changes were identified in the spleen, liver, and kidney. However, viral replication was only found in the spleen, which suggested the spleen to be the principle target organ of SFTSV. Moreover, the number of macrophages and platelets were largely increased in the spleen, and SFTSV colocalized with platelets in cytoplasm of macrophages in the red pulp of the spleen. In vitro cellular assays further revealed that SFTSV adhered to mouse platelets and facilitated the phagocytosis of platelets by mouse primary macrophages, which in combination with in vivo findings, suggests that SFTSV-induced thrombocytopenia is caused by clearance of circulating virus-bound platelets by splenic macrophages. Thus, this study has elucidated the pathogenic mechanisms of thrombocytopenia in a mouse model resembling human SFTS disease.
Related Links	http://dx.doi.org/10.1073/pnas.1120246109
Ending Page	10058
Page Count	6
Starting Page	10053
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-06-19
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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