NDLI: Langerhans cells are precommitted to immune tolerance induction

Content Provider	PubMed Central
Author	Elena, Shklovskaya O’sullivan, Brendan J. Ng, Lai Guan Roediger, Ben Thomas, Ranjeny Weninger, Wolfgang Groth, Barbara Fazekas De St
Abstract	Antigen-dependent interactions between T lymphocytes and dendritic cells (DCs) can produce two distinct outcomes: tolerance and immunity. It is generally considered that all DC subsets are capable of supporting both tolerogenic and immunogenic responses, depending on their exposure to activating signals. Here, we tested whether epidermal Langerhans cells (LCs) can support immunogenic responses in vivo in the absence of antigen presentation by other DC subsets. CD4 T cells responding to antigen presentation by activated LCs initially proliferated but then failed to differentiate into effector/memory cells or to survive long term. The tolerogenic function of LCs was maintained after exposure to potent adjuvants and occurred despite up-regulation of the costimulatory molecules CD80, CD86, and IL-12, but was consistent with their failure to translocate the NF-κB family member RelB from the cytoplasm to the nucleus. Commitment of LCs to tolerogenic function may explain why commensal microorganisms expressing Toll-like receptor (TLR) ligands but confined to the skin epithelium are tolerated, whereas invading pathogens that breach the epithelial basement membrane and activate dermal DCs stimulate a strong immune response.
Related Links	http://dx.doi.org/10.1073/pnas.1110076108
Ending Page	18054
Page Count	6
Starting Page	18049
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	44
Volume Number	108
Language	English
Publisher	National Academy of Sciences
Publisher Date	2011-11-01
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Langerhans cells are precommitted to immune tolerance induction.

Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance

Immune mechanisms of sublingual immunotherapy: are oral Langerhans cells the masters of tolerance?

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

The Roles of Skin Langerhans Cells in Immune Tolerance and Cancer Immunity

Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects.

R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms

Gut-tropic T Cells that Express Integrin α4β7 and CCR9 are Required for Induction of Oral Immune Tolerance in Mice

UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion.

Langerhans cells are precommitted to immune tolerance induction

Similar Documents

Langerhans cells are precommitted to immune tolerance induction.

Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance

Immune mechanisms of sublingual immunotherapy: are oral Langerhans cells the masters of tolerance?

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

The Roles of Skin Langerhans Cells in Immune Tolerance and Cancer Immunity

Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects.

R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms

Gut-tropic T Cells that Express Integrin α4β7 and CCR9 are Required for Induction of Oral Immune Tolerance in Mice

UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in humans: relationship to dose, CD1a-DR+ epidermal macrophage induction, and Langerhans cell depletion.

Langerhans cells are precommitted to immune tolerance induction