NDLI: GnRH - a Missing Link between Testosterone Concentrations in Yolk and Plasma and Its Intergenerational Effects

Content Provider	PubMed Central
Author	Müller, Wendt Groothuis, Ton G. G. Goerlich, Vivian C. Marcel, Eens
Editor	Iwaniuk, Andrew
Copyright Year	2011
Abstract	Despite the strong interest in hormone-mediated maternal effects two key questions concerning their mechanisms are as yet unanswered: First, whether the deposition of hormones in the egg yolk is coupled with the levels of these hormones in the maternal circulation, and second, whether epigenetic changes as induced by embryonic exposure to maternal yolk hormones impinge on yolk hormone deposition at adulthood. We investigated the responsiveness to gonadotropin-releasing hormone (GnRH) in female canaries whose embryonic exposure to yolk testosterone had been manipulated. This enabled us to study to what extent GnRH interlinks testosterone concentrations in female circulation and egg yolk as well as the intergenerational potential of hormone-mediated maternal effects. As expected, canary females responded to GnRH with a rise in plasma testosterone. The GnRH-responsiveness was positively correlated with the yolk testosterone content. Factors stimulating the release of GnRH will, therefore, lead to an increase of testosterone in both plasma and egg, posing a potential constraint on the yolk hormone deposition due to testosterone related trade-offs within the laying female. Exposure to elevated yolk testosterone levels as embryo reduced the GnRH-responsiveness in adulthood, potentially limiting environmental influences on yolk testosterone deposition, but the concentrations of yolk testosterone itself were not affected.
Related Links	http://dx.doi.org/10.1371/journal.pone.0022675
Starting Page	22675
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	7
Volume Number	6
Language	English
Publisher	Public Library of Science
Publisher Date	2011-07-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Elevated Plasma Corticosterone Decreases Yolk Testosterone and Progesterone in Chickens: Linking Maternal Stress and Hormone-Mediated Maternal Effects

Exploring Protein Dynamics Space: The Dynasome as the Missing Link between Protein Structure and Function

Austro-Asiatic Tribes of Northeast India Provide Hitherto Missing Genetic Link between South and Southeast Asia

Completing the cycle: maternal effects as the missing link in plant life histories

Revealing Missing Parts of the Interactome via Link Prediction

Systematic Reviews of Animal Studies; Missing Link in Translational Research?

Plasma Glutamine Concentrations in Liver Failure

Sex-specific effects of yolk testosterone on survival, begging and growth of zebra finches

A condition dependent link between testosterone and disease resistance in the house finch.

GnRH - a Missing Link between Testosterone Concentrations in Yolk and Plasma and Its Intergenerational Effects

Similar Documents

Elevated Plasma Corticosterone Decreases Yolk Testosterone and Progesterone in Chickens: Linking Maternal Stress and Hormone-Mediated Maternal Effects

Exploring Protein Dynamics Space: The Dynasome as the Missing Link between Protein Structure and Function

Austro-Asiatic Tribes of Northeast India Provide Hitherto Missing Genetic Link between South and Southeast Asia

Completing the cycle: maternal effects as the missing link in plant life histories

Revealing Missing Parts of the Interactome via Link Prediction

Systematic Reviews of Animal Studies; Missing Link in Translational Research?

Plasma Glutamine Concentrations in Liver Failure

Sex-specific effects of yolk testosterone on survival, begging and growth of zebra finches

A condition dependent link between testosterone and disease resistance in the house finch.

GnRH - a Missing Link between Testosterone Concentrations in Yolk and Plasma and Its Intergenerational Effects