NDLI: Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy

Content Provider	PubMed Central
Author	Labruna, Giuseppe Fabrizio, Pasanisi Fortunato, Giuliana Nardelli, Carmela Finelli, Carmine Eduardo, Farinaro Contaldo, Franco Sacchetti, Lucia
Copyright Year	2011
Abstract	Brown adipose tissue, where Uncoupling Protein 1 (UCP1) activity uncouples mitochondrial respiration, is an important site of facultative energy expenditure. This tissue may normally function to prevent obesity. Our aim was to investigate by sequence analysis the presence of UCP1 gene variations that may be associated with obesity. We studied 100 severe obese adults (BMI > 40 kg/m2) and 100 normal-weight control subjects (BMI range = 19–24.9 kg/m2). We identified 7 variations in the promoter region, 4 in the intronic region and 4 in the exonic region. Globally, 72% of obese patients bore UCP1 polymorphisms. Among UCP1 variants, g.IVS4−208T>G SNP was associated with obesity (OR: 1.77; 95% CI = 1.26–2.50; P = .001). Further, obese patients bearing the g.−451C>T (CT+TT) or the g.940G>A (GA+AA) genotypes showed a higher BMI than not polymorphic obese patients (P = .008 and P = .043, resp.). In conclusion, UCP1 SNPs could represent “thrifty” factors that promote energy storage in prone subjects.
Related Links	http://dx.doi.org/10.1155/2011/269043
Starting Page	269043
File Format	PDF
ISSN	20900716
e-ISSN	20900716
Journal	Journal of Obesity
Volume Number	2011
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism

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Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy

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Sequence Analysis of the UCP1 Gene in a Severe Obese Population from Southern Italy

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