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| Content Provider | PubMed Central |
|---|---|
| Author | Benjamin, Ashlee M. Sunil, Suchindran Pearce, Kaela Rowell, Jennifer Lien, Lillian F. Guyton, John R. Mccarthy, Jeanette J. |
| Copyright Year | 2011 |
| Abstract | Obesity is an increasingly prevalent and severe health concern with a substantial heritable component and marked sex differences. We sought to determine if the effect of genetic variants also differed by sex by performing a genome-wide association study modeling the effect of genotype-by-sex interaction on obesity phenotypes. Genotype data from individuals in the Framingham Heart Study Offspring cohort were analyzed across five exams. Although no variants showed genome-wide significant gene-by-sex interaction in any individual exam, four polymorphisms displayed a consistent BMI association (P-values .00186 to .00010) across all five exams. These variants were clustered downstream of LYPLAL1, which encodes a lipase/esterase expressed in adipose tissue, a locus previously identified as having sex-specific effects on central obesity. Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits. |
| Related Links | http://dx.doi.org/10.1155/2011/329038 |
| Starting Page | 329038 |
| File Format | |
| ISSN | 20900708 |
| e-ISSN | 20900716 |
| Journal | Journal of Obesity |
| Volume Number | 2011 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism |
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