NDLI: Mendelian Randomisation Study of Childhood BMI and Early Menarche

Content Provider	PubMed Central
Author	Mumby, Hannah S. Elks, Cathy E. Li, Shengxu Sharp, Stephen J. Khaw, Kay-tee Luben, Robert N. Wareham, Nicholas J. Loos, Ruth J. F. Ong, Ken K.
Copyright Year	2011
Abstract	To infer the causal association between childhood BMI and age at menarche, we performed a mendelian randomisation analysis using twelve established “BMI-increasing” genetic variants as an instrumental variable (IV) for higher BMI. In 8,156 women of European descent from the EPIC-Norfolk cohort, height was measured at age 39–77 years; age at menarche was self-recalled, as was body weight at age 20 years, and BMI at 20 was calculated as a proxy for childhood BMI. DNA was genotyped for twelve BMI-associated common variants (in/near FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, ETV5, MTCH2, SEC16B, FAIM2 and SH2B1), and for each individual a “BMI-increasing-allele-score” was calculated by summing the number of BMI-increasing alleles across all 12 loci. Using this BMI-increasing-allele-score as an instrumental variable for BMI, each 1 kg/m2 increase in childhood BMI was predicted to result in a 6.5% (95% CI: 4.6–8.5%) higher absolute risk of early menarche (before age 12 years). While mendelian randomisation analysis is dependent on a number of assumptions, our findings support a causal effect of BMI on early menarche and suggests that increasing prevalence of childhood obesity will lead to similar trends in the prevalence of early menarche.
Related Links	http://dx.doi.org/10.1155/2011/180729
Starting Page	180729
File Format	PDF
ISSN	20900716
e-ISSN	20900716
Journal	Journal of Obesity
Volume Number	2011
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mendelian Randomisation Study of Childhood BMI and Early Menarche

Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study

HOW DOES BODY FAT INFLUENCE BONE MASS IN CHILDHOOD? A MENDELIAN RANDOMISATION APPROACH

Mendelian randomisation studies of type 2 diabetes: future prospects

Mendelian randomisation studies of type 2 diabetes: future prospects

Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study

Early-childhood BMI trajectories: evidence from a prospective, nationally representative British cohort study

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

Mendelian Randomisation Study of Childhood BMI and Early Menarche

Similar Documents

Mendelian Randomisation Study of Childhood BMI and Early Menarche

Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study

HOW DOES BODY FAT INFLUENCE BONE MASS IN CHILDHOOD? A MENDELIAN RANDOMISATION APPROACH

Mendelian randomisation studies of type 2 diabetes: future prospects

Mendelian randomisation studies of type 2 diabetes: future prospects

Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study

Early-childhood BMI trajectories: evidence from a prospective, nationally representative British cohort study

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

Mendelian Randomisation Study of Childhood BMI and Early Menarche