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| Content Provider | PubMed Central |
|---|---|
| Author | Zhang, Mingdong Huang, Wen-yi Andreotti, Gabriella Gao, Yu-tang Rashid, Asif Chen, Jinbo Sakoda, Lori C. Shen, Ming-chang Wang, Bing-sheng Chanock, Stephen Hsing, Ann W. |
| Abstract | Biliary tract cancers, encompassing tumors of the gallbladder, extrahepatic ducts, and ampulla of Vater, are relatively rare tumors with a high fatality rate. Other than a close link with gallstones, the etiology of biliary tract cancers is poorly understood. We conducted a population-based case-control study in Shanghai, China, to examine whether genetic variants in several DNA repair genes are associated with biliary tract cancers or biliary stones. Genomic DNA from 411 patients with biliary tract cancers (237 gallbladder, 127 bile duct, and 47 ampulla of Vater), 891 patients with biliary stones, and 786 healthy subjects randomly selected from the Shanghai population, was genotyped for 6 single nucleotide polymorphisms (SNPs) in 4 DNA repair genes (MGMT, RAD23B, CCNH, and XRCC3). Of the 6 SNPs, only one (MGMT EX5-25C>T, rs12917) was associated with biliary tract cancer. Independent of gallstones, subjects carrying the CT genotype of the MGMT EX5-25C>T marker had a significantly reduced risk of gallbladder cancer (odds ratio (OR)=0.63; 95% confidence interval (CI): 0.41-0.97; P trend = 0.02) and non-significant reduced risks of bile duct (OR=0.61; 95% CI: 0.35-1.06) and ampulla of Vater (OR=0.85; 95% CI: 0.39-1.87) cancers. However, this marker was not associated with biliary stones, and the other markers examined were not significantly associated with either biliary tract cancers or stones. Findings from this population-based study in Shanghai suggest that MGMT gene variants may alter susceptibility to biliary tract cancer, particularly gallbladder cancer. Confirmation in future studies, however, is required. |
| Related Links | http://dx.doi.org/10.1158/1055-9965.EPI-07-2735 |
| Starting Page | 2123 |
| File Format | |
| ISSN | 15387755 |
| e-ISSN | 15387755 |
| Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| Issue Number | 8 |
| Volume Number | 17 |
| Language | English |
| Publisher Date | 2008-08-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Epidemiology Oncology |
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