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| Content Provider | PubMed Central |
|---|---|
| Author | Hsing, Ann W. Sakoda, Lori C. Rashid, Asif Andreotti, Gabriella Chen, Jinbo Wang, Bin-shen Shen, Ming-chang Chen, Bingshu E. Rosenberg, Philip S. Zhang, Mingdong Niwa, Shelley Chu, Lisa Welch, Robert Yeager, Meredith Fraumeni, Joseph F. Gao, Yu-tang Chanock, Stephen J. |
| Abstract | To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), including 22 inflammation-related genes, based on a population-based case-control study conducted in Shanghai, China, where the incidence of biliary tract cancer has been increasing in recent decades. The study included 411 cases with biliary tract cancer (237 gallbladder, 127 extrahepatic bile duct, and 47 ampulla of Vater), 895 with biliary stones, and 786 controls randomly selected from the population. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of individual single nucleotide polymorphisms (SNPs) and haplotypes with biliary stones and biliary tract cancer. Of the 62 SNPs examined, 14 were related to the risk of biliary cancer and stones. Specifically, variants in the IL8, IL8RB, RNASEL, and NOS2 genes were associated with biliary stones, while VEGF variants were associated with gallbladder cancer. Of the 10 genes with multiple SNPs from which we inferred haplotypes, only one IL8RB haplotype, consisting of 3 SNPs (rs2230054, rs1126579, rs1126580), was associated with the risk of bile duct cancer (p=0.003) and biliary stones (p=0.02), relative to the most frequent haplotype. In summary, common variants in genes that influence inflammatory responses may predispose to gallstones and biliary tract cancer, suggesting the need for future studies into the immunologic and inflammatory pathways that contribute to biliary diseases, including cancer. |
| Related Links | http://dx.doi.org/10.1158/0008-5472.can-08-0444 |
| Ending Page | 6452 |
| Page Count | 11 |
| Starting Page | 6442 |
| File Format | |
| ISSN | 00085472 |
| e-ISSN | 15387445 |
| Journal | Cancer research |
| Issue Number | 15 |
| Volume Number | 68 |
| Language | English |
| Publisher Date | 2008-08-01 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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