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| Content Provider | PubMed Central |
|---|---|
| Author | Wang, Xianshu Goode, Ellen L. Fredericksen, Zachary S. Vierkant, Robert A. Pankratz, V. Shane Rider, David N. Vachon, Celine M. Cerhan, James R. Olson, Janet E. Couch, Fergus J. |
| Abstract | Aberrant Wnt/β-catenin signaling leading to nuclear accumulation of the oncogene product β-catenin is observed in a wide spectrum of human malignancies. The destruction complex in the Wnt/β-catenin pathway is critical for regulating the level of β-catenin in the cytoplasm and in the nucleus. Here we report a comprehensive study of the contribution of genetic variation in six genes encoding the β-catenin destruction complex (APC, AXIN1, AXIN2, CSNK1D, CSNK1E and GSK3B) to breast cancer using a Mayo Clinic Breast Cancer Case-Control Study. A total of 79 candidate functional and tagSNPs were genotyped in 798 invasive cases and 843 unaffected controls. Of these, rs454886 in the APC tumor suppressor gene was associated with increased breast cancer risk (per-allele odds ratio (OR) = 1.23; 95% CI, 1.05–1.43; P trend = 0.01). In addition, five SNPs in AXIN2 were associated with increased risk of breast cancer (P trend < 0.05). Haplotype-based tests identified significant associations between specific haplotypes in APC (P ≤ 0.03) and AXIN2 (P = 0.03) and breast cancer risk. Further characterization of the APC and AXIN2 variants suggested that AXIN2 rs4791171 was significantly associated with risk in premenopausal (P trend = 0.0002; q = 0.02) but not in postmenopausal women. The combination of our findings and numerous genetic and functional studies showing that APC and AXIN2 perform crucial tumor suppressor functions suggest that further investigation of the contribution of AXIN2 and APC SNPs to breast cancer risk are needed. |
| Related Links | http://dx.doi.org/10.1158/1055-9965.EPI-08-0134 |
| Starting Page | 2101 |
| File Format | |
| ISSN | 15387755 |
| e-ISSN | 15387755 |
| Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| Issue Number | 8 |
| Volume Number | 17 |
| Language | English |
| Publisher Date | 2008-08-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Epidemiology Oncology |
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