NDLI: Viral infection of the thymus.

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Nucleotide 880 splice donor site required for efficient transformation and RNA accumulation by human papillomavirus type 16 E7 gene.

Human immunodeficiency virus vectors for inducible expression of foreign genes.

Structural and functional characterization of the poliovirus replication complex.

Recombinant vaccine for canine parvovirus in dogs.

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Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene.

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Transformation-dependent expression of interleukin genes delivered by a recombinant parvovirus.

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Regulation of the Epstein-Barr virus DNA polymerase gene.

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Insertional mutagenesis of flvi-2 in tumors induced by infection with LC-FeLV, a myc-containing strain of feline leukemia virus.

Use of second-site homologous recombination to demonstrate that Epstein-Barr virus nuclear protein 3B is not important for lymphocyte infection or growth transformation in vitro.

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Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression.

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Regulated expression of foreign genes in vaccinia virus under the control of bacteriophage T7 RNA polymerase and the Escherichia coli lac repressor.

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Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1.

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Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter.

Ternary complex formation by vaccinia virus RNA polymerase at an early viral promoter: analysis by native gel electrophoresis.

Modification of some biological properties of HeLa cells containing adeno-associated virus DNA integrated into chromosome 17.

Characterization of a 7-kilodalton subunit of vaccinia virus DNA-dependent RNA polymerase with structural similarities to the smallest subunit of eukaryotic RNA polymerase II.

An early event in murine cytomegalovirus replication inhibits presentation of cellular antigens to cytotoxic T lymphocytes.

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Spleen necrosis virus, an avian immunosuppressive retrovirus, shares a receptor with the type D simian retroviruses.

Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system.

Identification of T-helper epitopes in the VP1 capsid protein of poliovirus.

Identification and characterization of pseudorabies virus glycoprotein H.

Transactivation of erythroid transcription factor GATA-1 by a myb-ets-containing retrovirus.

Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter.

Coding capacity determines in vivo accumulation of a defective RNA of clover yellow mosaic virus.

Expression of Aleutian mink disease parvovirus capsid proteins by a recombinant vaccinia virus: self-assembly of capsid proteins into particles.

Characterization of hepatitis B virus capsid particle assembly in Xenopus oocytes.

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Specific interactions of HeLa cell proteins with proposed translation domains of the poliovirus 5' noncoding region.

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Nuclear factor I is specifically targeted to discrete subnuclear sites in adenovirus type 2-infected cells.

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Viral infection of the thymus.

Poliovirus chimeras expressing sequences from the principal neutralization domain of human immunodeficiency virus type 1.

Evidence for zinc binding by two structural proteins of Plodia interpunctella granulosis virus.

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Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis.

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule.

Theiler's virus replication in brain macrophages cultured in vitro.

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Replication of plasmid-derived human papillomavirus type 11 DNA in cultured keratinocytes.

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Expression and extracellular release of human immunodeficiency virus type 1 Gag precursors by recombinant baculovirus-infected cells.

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Functional analysis of the true late human cytomegalovirus pp28 upstream promoter: cis-acting elements and viral trans-acting proteins necessary for promoter activation.

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Cytolytic T lymphocytes specific for tumors and infected cells from mice with a retrovirus-induced immunodeficiency syndrome.

Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma.

Nuclear entry and nucleolar localization of the Newcastle disease virus (NDV) matrix protein occur early in infection and do not require other NDV proteins.

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Viral infection of the thymus.

Content Provider	PubMed Central
Author	King, C. C. Jamieson, B. D. Reddy, K. Bali, N. Concepcion, R. J. Ahmed, R.
Abstract	We have examined infection of the thymus during congenitally acquired chronic lymphocytic choriomeningitis virus (LCMV) infection of mice, a classic model of antigen-specific T-cell tolerance. Our results show that (i) infection starts at the fetal stage and is maintained throughout adulthood, and (ii) this chronic infection of the thymus can be eliminated by transfer of virus-specific cytotoxic T lymphocytes (CTL) that infiltrate the thymus and clear all viral products from both medullary and cortical regions. Elimination of virus from the thymus results in abrogation of tolerance. During the fetal stage, the predominant cell type infected is the earliest precursor of T cells with a surface phenotype of Thy1+ CD4- CD8- J11d+. In the adult thymus, infection is confined primarily to the cortisone-resistant thymocytes present in the medullary region. The infected cells are CD4+ and J11d+. The presence of J11d, a marker usually associated with immature thymocytes, on infected single positive CD4+ "mature" thymocytes is intriguing and suggests that infection by this noncytolytic virus may affect development of T cells. There is minimal infection of the CD8+ medullary thymocytes or of the double positive (CD4+ CD8+) cells present in the cortex. Infection within the cortex is confined to the stromal cells. Interestingly, there is infection of the double negative (CD4- CD8-) thymocytes in the adult thymus, showing that even during adulthood the newly developing T cells are susceptible to infection by LCMV. Virus can be eliminated from the thymuses of these carrier mice by adoptive transfer of medullary region first and then from the thymic cortex. This result clearly shows the need to reevaluate the widely held notion that mature T cells are unable to reenter the thymus. In fact, in our experiments the donor T cells made up to 20 to 30% of the total cells in the thymus at 5 to 7 days after the transfer. The number of donor T cells declined as virus was eliminated from the thymus, and at 1 month posttransfer, the donor T cells were hardly detectable. The results of this study examining the dynamics of viral infection and clearance from the thymus, the primary site of T-cell development, have implications for understanding tolerance induction in chronic viral infections.
Starting Page	3155
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	5
Volume Number	66
Language	English
Publisher Date	1992-05-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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