NDLI: Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are 3' coterminal and encode a putative zinc finger transactivator protein.

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Heterologous recombination in the double-stranded RNA bacteriophage phi 6.

In vitro packaging and replication of individual genomic segments of bacteriophage phi 6 RNA.

Molecular attenuation of vaccinia virus: mutant generation and animal characterization.

Expression of the Marek's disease virus (MDV) homolog of glycoprotein B of herpes simplex virus by a recombinant baculovirus and its identification as the B antigen (gp100, gp60, gp49) of MDV.

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Identification and characterization of the herpes simplex virus type 1 virion protein encoded by the UL35 open reading frame.

Specific lysis of targets expressing varicella-zoster virus gpI or gpIV by CD4+ human T-cell clones.

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Association of ICP0 but not ICP27 with purified virions of herpes simplex virus type 1.

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Human immunodeficiency virus vectors for inducible expression of foreign genes.

Structural and functional characterization of the poliovirus replication complex.

Recombinant vaccine for canine parvovirus in dogs.

Stable rescue of a glycoprotein gII deletion mutant of pseudorabies virus by glycoprotein gI of bovine herpesvirus 1.

Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are 3' coterminal and encode a putative zinc finger transactivator protein.

Establishment and functional characterization of human herpesvirus 6-specific CD4+ human T-cell clones.

Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen.

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Molecular characterization of a neuropathogenic and nonerythroleukemogenic variant of Friend murine leukemia virus PVC-211.

Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene.

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Transformation-dependent expression of interleukin genes delivered by a recombinant parvovirus.

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Insertional mutagenesis of flvi-2 in tumors induced by infection with LC-FeLV, a myc-containing strain of feline leukemia virus.

Use of second-site homologous recombination to demonstrate that Epstein-Barr virus nuclear protein 3B is not important for lymphocyte infection or growth transformation in vitro.

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Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression.

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Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter.

Ternary complex formation by vaccinia virus RNA polymerase at an early viral promoter: analysis by native gel electrophoresis.

Modification of some biological properties of HeLa cells containing adeno-associated virus DNA integrated into chromosome 17.

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Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system.

Identification of T-helper epitopes in the VP1 capsid protein of poliovirus.

Identification and characterization of pseudorabies virus glycoprotein H.

Transactivation of erythroid transcription factor GATA-1 by a myb-ets-containing retrovirus.

Infection of HeLa cells with poliovirus results in modification of a complex that binds to the rRNA promoter.

Coding capacity determines in vivo accumulation of a defective RNA of clover yellow mosaic virus.

Expression of Aleutian mink disease parvovirus capsid proteins by a recombinant vaccinia virus: self-assembly of capsid proteins into particles.

Characterization of hepatitis B virus capsid particle assembly in Xenopus oocytes.

5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate.

Specific interactions of HeLa cell proteins with proposed translation domains of the poliovirus 5' noncoding region.

Defective synthesis of early region 4 mRNAs during abortive adenovirus infections in monkey cells.

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Mapping genetic determinants for human immunodeficiency virus type 1 resistance to soluble CD4.

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Viral infection of the thymus.

Poliovirus chimeras expressing sequences from the principal neutralization domain of human immunodeficiency virus type 1.

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Theiler's virus replication in brain macrophages cultured in vitro.

A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.

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Replication of plasmid-derived human papillomavirus type 11 DNA in cultured keratinocytes.

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Cytolytic T lymphocytes specific for tumors and infected cells from mice with a retrovirus-induced immunodeficiency syndrome.

Consistent transcription of the Epstein-Barr virus LMP2 gene in nasopharyngeal carcinoma.

Nuclear entry and nucleolar localization of the Newcastle disease virus (NDV) matrix protein occur early in infection and do not require other NDV proteins.

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Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are 3' coterminal and encode a putative zinc finger transactivator protein.

Content Provider	PubMed Central
Author	Fraefel, C. Vogt, B. Vlcek, C. Schwyzer, M. Wirth, U. V. Paces, V.
Abstract	Bovine herpesvirus 1 (BHV-1) contains three major immediate-early (IE) genes involved in regulation of the productive cycle of replication. Two spliced IE RNAs, IER4.2 (4.2 kb) and IER2.9 (2.9 kb), are under the control of a single promoter; IER1.7 (1.7 kb) is transcribed from a different promoter in the opposite direction. Examining the kinetics of transcription, we found that the IER4.2/2.9 promoter was turned off at the end of the IE period. An alternative promoter became active, directing synthesis of an unspliced early RNA, ER2.6 (2.6 kb), which was colinear with the second exon of IER2.9 except for its 5' end in the intron about 10 bases upstream of the splice site. Sequence analysis revealed a single open reading frame common to IER2.9 and ER2.6 with a coding potential of 676 amino acids. The putative protein, named p135, contained a cysteine-rich zinc finger domain near the N terminus with homology to ICP0 of herpes simplex virus type 1, to protein 61 of varicella-zoster virus, to early protein 0 of pseudorabies virus, and to other viral and cellular proteins. The remaining parts of p135 exhibited only limited homology, mainly with pseudorabies virus protein 0, but the entire sequence was highly conserved between two strains of BHV-1 (K22 and Jura). The latency-related antisense transcript covered a large portion of ER2.6 excluding the zinc finger coding region. In transient expression assays, p135 activated a variety of promoters, including that for ER2.6, but repressed the IER1.7 promoter. Thus, p135 combines functional characteristics of ICP0, a strong transactivator, and of protein 61, a repressor. BHV-1 seems to have evolved a subtle mechanism to ensure the continued synthesis of p135 while turning off IER4.2, which encodes p180, the herpes simplex virus type 1 ICP4 homolog.
Starting Page	2763
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	5
Volume Number	66
Language	English
Publisher Date	1992-05-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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