NDLI: Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei

Content Provider	PubMed Central
Author	Zink, Daniele Amaral, Margarida D. Andreas, Englmann Lang, Susanne Clarke, Luka A. Rudolph, Carsten Alt, Felix Luther, Kathrin Braz, Carla Nicolas, Sadoni Joseph, Rosenecker Dirk, Schindelhauer
Abstract	We investigated in different human cell types nuclear positioning and transcriptional regulation of the functionally unrelated genes GASZ, CFTR, and CORTBP2, mapping to adjacent loci on human chromosome 7q31. When inactive, GASZ, CFTR, and CORTBP2 preferentially associated with the nuclear periphery and with perinuclear heterochromatin, whereas in their actively transcribed states the gene loci preferentially associated with euchromatin in the nuclear interior. Adjacent genes associated simultaneously with these distinct chromatin fractions localizing at different nuclear regions, in accordance with their individual transcriptional regulation. Although the nuclear localization of CFTR changed after altering its transcription levels, the transcriptional status of CFTR was not changed by driving this gene into a different nuclear environment. This implied that the transcriptional activity affected the nuclear positioning, and not vice versa. Together, the results show that small chromosomal subregions can display highly flexible nuclear organizations that are regulated at the level of individual genes in a transcription-dependent manner.
Related Links	http://dx.doi.org/10.1083/jcb.200404107
Ending Page	825
Page Count	11
Starting Page	815
File Format	PDF
ISSN	00219525
e-ISSN	15408140
Journal	The Journal of Cell Biology
Issue Number	6
Volume Number	166
Language	English
Publisher	The Rockefeller University Press
Publisher Date	2004-09-13
Access Restriction	Open
Rights Holder	The Rockefeller University Press
Subject Keyword	Cell Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine

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