NDLI: LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing

Content Provider	PubMed Central
Author	Screaton, Gavin R. Xu, Xiao-ning Olsen, Anna L. Cowper, Alison E. Tan, Rusung Mcmichael, Andrew J. Bell, John I.
Copyright Year	1997
Abstract	Fas and TNF-R1 are cysteine-rich cell surface receptors related to the low-affinity nerve growth factor receptor family. Engagement of these receptors by their respective ligands, FasL and tumor necrosis factor, leads to apoptosis that is signaled through a conserved intracellular portion of the receptor termed the “death domain.” We have cloned a new member of this family, lymphocyte-associated receptor of death (LARD), which leads to spontaneous apoptosis when expressed in 293T cells. The expression of LARD is more tightly regulated than that of either Fas or TNF-R1 as it is found predominantly on lymphocytes (T and B cells) but not on macrophages or a number of transformed lymphocyte cell lines. Alternative pre-mRNA splicing generates at least 11 distinct isoforms of LARD. The full-length isoform, LARD-1, extends to include the transmembrane and death domains, whereas the other isoforms encode potentially secreted molecules. Naive B and T cells express very little LARD-1 but express combinations of the other isoforms. Upon T cell activation, a programmed change in alternative splicing occurs so that the full-length, membrane-bound LARD-1 predominates. This may have implications for the control of lymphocyte proliferation following activation.
Starting Page	4615
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	94
Language	English
Publisher	The National Academy of Sciences of the USA
Publisher Date	1997-04-29
Access Restriction	Open
Rights Holder	The National Academy of Sciences of the USA
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing.

Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse

Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3′ acceptor site

Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors

Control of alternative pre-mRNA splicing by distributed pentameric repeats

Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA.

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

Alternative splicing in exon 9 of glucocorticoid receptor pre-mRNA is regulated by SRp40

Paraquat Modulates Alternative Pre-mRNA Splicing by Modifying the Intracellular Distribution of SRPK2

LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing

Similar Documents

LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing.

Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse

Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3′ acceptor site

Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors

Control of alternative pre-mRNA splicing by distributed pentameric repeats

Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA.

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors.

Alternative splicing in exon 9 of glucocorticoid receptor pre-mRNA is regulated by SRp40

Paraquat Modulates Alternative Pre-mRNA Splicing by Modifying the Intracellular Distribution of SRPK2

LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing