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| Content Provider | PubMed Central |
|---|---|
| Author | Sjögren, Maria Alkemade, Anneke Mittag, Jens Nordström, Kristina Katz, Abram Rozell, Björn Westerblad, Håkan Arner, Anders Vennström, Björn |
| Copyright Year | 2007 |
| Abstract | Thyroid hormone, via its nuclear receptors TRα and TRβ, controls metabolism by acting locally in peripheral tissues and centrally by regulating sympathetic signaling. We have defined aporeceptor regulation of metabolism by using mice heterozygous for a mutant TRα1 with low affinity to T3. The animals were hypermetabolic, showing strongly reduced fat depots, hyperphagia and resistance to diet-induced obesity accompanied by induction of genes involved in glucose handling and fatty acid metabolism in liver and adipose tissues. Increased lipid mobilization and β-oxidation occurred in adipose tissues, whereas blockade of sympathetic signaling to brown adipose tissue normalized the metabolic phenotype despite a continued perturbed hormone signaling in this cell type. The results define a novel and important role for the TRα1 aporeceptor in governing metabolic homeostasis. Furthermore, the data demonstrate that a nuclear hormone receptor affecting sympathetic signaling can override its autonomous effects in peripheral tissues. |
| Related Links | http://dx.doi.org/10.1038/sj.emboj.7601882 |
| Starting Page | 4535 |
| File Format | |
| ISSN | 14602075 |
| e-ISSN | 14602075 |
| Journal | The EMBO Journal |
| Issue Number | 21 |
| Volume Number | 26 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2007-10-31 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Immunology and Microbiology Medicine Molecular Biology |
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