NDLI: Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions.

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Expression status of Tax protein in human T-cell leukemia virus type 1-transformed MT4 cells: recall of MT4 cells distributed by the NIH AIDS Research and Reference Reagent Program.

Transformation and tumorigenic properties of a mutant polyomavirus containing a middle T antigen defective in Shc binding.

Detection of an interaction between the HN and F proteins in Newcastle disease virus-infected cells.

Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor.

Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.

Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His).

The potent enhancer activity of the polycythemic strain of spleen focus-forming virus in hematopoietic cells is governed by a binding site for Sp1 in the upstream control region and by a unique enhancer core motif, creating an exclusive target for PEBP/CBF.

Evolution of the human immunodeficiency virus type 1 subtype-specific V3 domain is confined to a sequence space with a fixed distance to the subtype consensus.

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.

pol gene diversity of five human immunodeficiency virus type 1 subtypes: evidence for naturally occurring mutations that contribute to drug resistance, limited recombination patterns, and common ancestry for subtypes B and D.

Placental trophoblasts resist infection by multiple human immunodeficiency virus (HIV) type 1 variants even with cytomegalovirus coinfection but support HIV replication after provirus transfection.

In vitro study of the NS2-3 protease of hepatitis C virus.

Role of preterminal protein processing in adenovirus replication.

The catalytic subunit of the DNA polymerase of herpes simplex virus type 1 interacts specifically with the C terminus of the UL8 component of the viral helicase-primase complex.

A 45,000-M(r) glycoprotein in the Sendai virus envelope triggers virus-cell fusion.

Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses.

A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activity.

Isolation and characterization of human papillomavirus type 6-specific T cells infiltrating genital warts.

Translation elongation factor-1 alpha interacts with the 3' stem-loop region of West Nile virus genomic RNA.

Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter.

Characterization of pseudorabies virus mutants expressing carboxy-terminal truncations of gE: evidence for envelope incorporation, virulence, and neurotropism domains.

Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis.

Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.

Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists.

Modulation of RANTES production by human cytomegalovirus infection of fibroblasts.

Identification of GB virus C variants by phylogenetic analysis of 5'-untranslated and coding region sequences.

Simian immunodeficiency virus variants with differential T-cell and macrophage tropism use CCR5 and an unidentified cofactor expressed in CEMx174 cells for efficient entry.

Primary structure of the alcelaphine herpesvirus 1 genome.

Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.

Genetic determinant of rapid-onset B-cell lymphoma by avian leukosis virus.

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Activation domain requirements for disruption of Epstein-Barr virus latency by ZEBRA.

A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.

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Characterization of the minute virus of mice P38 core promoter elements.

Molecular characterization of the type-specific gamma-determinant located on the adenovirus fiber.

Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism.

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Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures.

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Human immunodeficiency virus type 1 infection of mature CD3hiCD8+ thymocytes.

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Binding of SP1 to the immediate-early protein-responsive element of the human cytomegalovirus DNA polymerase promoter.

Glycoprotein Erns of pestiviruses induces apoptosis in lymphocytes of several species.

Repeated emergence of epidemic/epizootic Venezuelan equine encephalitis from a single genotype of enzootic subtype ID virus.

Neuraminidase hemadsorption activity, conserved in avian influenza A viruses, does not influence viral replication in ducks.

The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency.

Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X.

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Functional and structural analysis of the sialic acid-binding domain of rotaviruses.

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Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements.

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Sequence variation within a nonstructural region of the hepatitis G virus genome.

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Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma.

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Poliovirus Sabin type 1 neutralization epitopes recognized by immunoglobulin A monoclonal antibodies.

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Cyclophilin A-induced alterations of human immunodeficiency virus type 1 CA protein in vitro.

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.

Priming with live respiratory syncytial virus (RSV) prevents the enhanced pulmonary inflammatory response seen after RSV challenge in BALB/c mice immunized with formalin-inactivated RSV.

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cis elements that contribute to geminivirus transcriptional regulation and the efficiency of DNA replication.

Cell-type-specific separate regulation of the E6 and E7 promoters of human papillomavirus type 6a by the viral transcription factor E2.

Functional interactions between monomers of the retroviral envelope protein complex.

Mutations in the N-terminal domain of human immunodeficiency virus type 1 nucleocapsid protein affect virion core structure and proviral DNA synthesis.

Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax.

Multimerization of polyomavirus middle-T antigen.

Mutational analysis of the adeno-associated virus type 2 Rep68 protein helicase motifs.

Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase.

The critical N-linked glycan of murine leukemia virus envelope protein promotes both folding of the C-terminal domains of the precursor polyprotein and stability of the postcleavage envelope complex.

Cell and viral regulatory elements enhance the expression and function of a human immunodeficiency virus inhibitory gene.

The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).

Herpes simplex virus genome replication and transcription during induced reactivation in the rabbit eye.

The UL84 protein of human cytomegalovirus acts as a transdominant inhibitor of immediate-early-mediated transactivation that is able to prevent viral replication.

Infectious particles derived from Semliki Forest virus vectors encoding murine leukemia virus envelopes.

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Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode.

Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions.

Expression and characterization of recombinant murine cytomegalovirus protease.

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Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins.

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Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions.

Content Provider	PubMed Central
Author	Dorfman, T. Weimann, A. Borsetti, A. Walsh, C. T. Göttlinger, H. G.
Abstract	Human immunodeficiency virus type 1 (HIV-1) incorporates the cellular peptidyl-prolyl cis-trans isomerase cyclophilin A (CyPA), the cytosolic receptor for the immunosuppressant cyclosporin A (CsA). CsA inhibits the incorporation of CyPA and reduces HIV-1 virion infectivity but is inactive against closely related primate lentiviruses that do not interact with CyPA. The incorporation of CyPA into HIV-1 virions is mediated by a specific interaction with a proline-containing, solvent-exposed loop in the capsid (CA) domain of the Gag polyprotein. CsA, which disrupts the interaction with CA, binds at the active site of CyPA. To test whether active-site residues are also involved in the interaction with HIV-1 CA, we used a panel of previously characterized active-site mutants of human CyPA. Expression vectors for epitope-tagged wild-type and mutant CyPA were transfected into COS-gamma cells along with HIV-1 proviral DNA, and the virions produced were analyzed for the presence of tagged proteins. Cotransfection of the wild-type expression vector led to the incorporation of readily detectable amounts of epitope-tagged CyPA into HIV-1 virions. One CyPA mutant with a substantially decreased sensitivity to CsA was incorporated with wild-type efficiency, demonstrating that the requirements for binding to CsA and to HIV-1 CA are not identical. The remaining six CyPA mutants were incorporated with markedly reduced efficiency, providing in vivo evidence that HIV-1 CA interacts with the active site of CyPA.
Starting Page	7110
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	9
Volume Number	71
Language	English
Publisher Date	1997-09-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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