NDLI: The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection.

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Localized sequence heterogeneity in the long terminal repeats of in vivo isolates of equine infectious anemia virus.

Genomic diversity and evolution of papillomaviruses in rhesus monkeys.

Analysis of the gene start and gene end signals of human respiratory syncytial virus: quasi-templated initiation at position 1 of the encoded mRNA.

Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.

Biochemical characterizations of two temperature-sensitive and attenuated strains of respiratory syncytial virus subgroup B.

Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses.

Protection of human immunodeficiency virus type 2-exposed seronegative macaques from mucosal simian immunodeficiency virus transmission.

GB virus B and hepatitis C virus NS3 serine proteases share substrate specificity.

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The shiverer mutation affects the persistence of Theiler's virus in the central nervous system.

Identification and characterization of a baculovirus structural protein, VP1054, required for nucleocapsid formation.

The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection.

Specific targeting to CD4+ cells of recombinant vesicular stomatitis viruses encoding human immunodeficiency virus envelope proteins.

Evolution of envelope-specific antibody responses in monkeys experimentally infected or immunized with simian immunodeficiency virus and its association with the development of protective immunity.

Stability of AML1 (core) site enhancer mutations in T lymphomas induced by attenuated SL3-3 murine leukemia virus mutants.

A mechanism for negative gene regulation in Autographa californica multinucleocapsid nuclear polyhedrosis virus.

Restoration of interferon responses of adenovirus E1A-expressing HT1080 cell lines by overexpression of p48 protein.

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Molecular basis for the differential subcellular localization of the 38- and 39-kilodalton structural proteins of Borna disease virus.

Biological characterization of human immunodeficiency virus type 1 clones derived from different organs of an AIDS patient by long-range PCR.

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Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b.

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cis-Acting sequences in addition to donor and acceptor sites are required for template switching during synthesis of plus-strand DNA for duck hepatitis B virus.

Insertions within epsilon affect synthesis of minus-strand DNA before the template switch for duck hepatitis B virus.

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Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice.

Infectious RNA transcripts from full-length dengue virus type 2 cDNA clones made in yeast.

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Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition.

Characterization of a novel third member of the human cytomegalovirus glycoprotein H-glycoprotein L complex.

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Vpr of simian immunodeficiency virus of African green monkeys is required for replication in macaque macrophages and lymphocytes.

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Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection.

Evidence for translation of the Borna disease virus G protein by leaky ribosomal scanning and ribosomal reinitiation.

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Genetic analysis of interactions between Gag proteins of Rous sarcoma virus.

Identification of an ATPase activity associated with a 71-kilodalton polypeptide encoded in gene 1 of the human coronavirus 229E.

The pseudorabies virus UL51 gene product is a 30-kilodalton virion component.

The UL20 gene product of pseudorabies virus functions in virus egress.

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Rhabdovirus-induced apoptosis in a fish cell line is inhibited by a human endogenous acid cysteine proteinase inhibitor.

Adeno-associated virus type 2-mediated transfer of ecotropic retrovirus receptor cDNA allows ecotropic retroviral transduction of established and primary human cells.

Subunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity.

Fish nodavirus lytic cycle and semipermissive expression in mammalian and fish cell cultures.

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The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-kappaB during infection.

Content Provider	PubMed Central
Author	Yurochko, A. D. Hwang, E. S. Rasmussen, L. Keay, S. Pereira, L. Huang, E. S.
Abstract	The cellular transcription factors Sp1 and NF-kappaB were upregulated shortly after the binding of purified live or UV-inactivated human cytomegalovirus (HCMV) to the cell surface. The rapid time frame of transcription factor induction is similar to that seen in other systems in which cellular factors are induced following receptor-ligand engagement. This similarity suggested that a cellular receptor-viral ligand interaction might be involved in Sp1 and NF-kappaB activation during the earliest stages of HCMV infection. To focus on the possible role viral ligands play in initiating cellular events following infection, we first used purified viral membrane extracts to demonstrate that constituents on the membrane are responsible for cellular activation. Additionally, these studies showed, through the use of neutralizing antibodies, that the viral membrane mediators of this activation are the major envelope glycoproteins gB (UL55) and gH (UL75). To confirm these results, neutralizing anti-gB and -gH antibodies were used to block the interactions of these glycoproteins on whole purified virus with their cell surface receptors. In so doing, we found that Sp1 and NF-kappaB induction was inhibited. Lastly, through the use of purified viral gB protein and an anti-idiotypic antibody that mimics the image of the viral gH protein, it was found that the engagement of individual viral ligands with their appropriate cell surface receptors was sufficient to activate cellular Sp1 and NF-kappaB. These results support our hypothesis that HCMV glycoproteins mediate an initial signal transduction pathway which leads to the upregulation of host cell transcription factors and suggests a model wherein the orderly sequence of virus-mediated changes in cellular activation initiates with viral binding via envelope glycoproteins to the cognate cellular receptor(s).
Starting Page	5051
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	7
Volume Number	71
Language	English
Publisher Date	1997-07-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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