NDLI: Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia

Content Provider	PubMed Central
Author	Levenson, Jonathan Endo, Shogo Kategaya, Lorna S. Fernandez, Raymond I. Brabham, David G. Chin, Jeannie Byrne, John H. Eskin, Arnold
Copyright Year	2000
Abstract	An increase in transmitter release accompanying long-term sensitization and facilitation occurs at the glutamatergic sensorimotor synapse of Aplysia. We report that a long-term increase in neuronal Glu uptake also accompanies long-term sensitization. Synaptosomes from pleural-pedal ganglia exhibited sodium-dependent, high-affinity Glu transport. Different treatments that induce long-term enhancement of the siphon-withdrawal reflex, or long-term synaptic facilitation increased Glu uptake. Moreover, 5-hydroxytryptamine, a treatment that induces long-term facilitation, also produced a long-term increase in Glu uptake in cultures of sensory neurons. The mechanism for the increase in uptake is an increase in the V max of transport. The long-term increase in Glu uptake appeared to be dependent on mRNA and protein synthesis, and transport through the Golgi, because 5,6-dichlorobenzimidazole riboside, emetine, and brefeldin A inhibited the increase in Glu uptake. Also, injection of emetine and 5,6-dichlorobenzimidazole into Aplysia prevented long-term sensitization. Synthesis of Glu itself may be regulated during long-term sensitization because the same treatments that produced an increase in Glu uptake also produced a parallel increase in Gln uptake. These results suggest that coordinated regulation of a number of different processes may be required to establish or maintain long-term synaptic facilitation.
Related Links	http://dx.doi.org/10.1073/pnas.220256497
Ending Page	12863
Page Count	6
Starting Page	12858
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	97
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2000-11-07
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia.

Post-translational Regulation of an Aplysia Glutamate Transporter During Long-Term Facilitation

Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia

Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai

Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia

A tropomyosin-related kinase B ligand is required for ERK activation, long-term synaptic facilitation, and long-term memory in Aplysia

Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses.

Circadian modulation of long-term sensitization in Aplysia

Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons.

Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia

Similar Documents

Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia.

Post-translational Regulation of an Aplysia Glutamate Transporter During Long-Term Facilitation

Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia

Transcriptome analysis and identification of regulators for long-term plasticity in Aplysia kurodai

Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia

A tropomyosin-related kinase B ligand is required for ERK activation, long-term synaptic facilitation, and long-term memory in Aplysia

Induction of long-term facilitation in Aplysia sensory neurons by local application of serotonin to remote synapses.

Circadian modulation of long-term sensitization in Aplysia

Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons.

Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia