NDLI: RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors

Content Provider	PubMed Central
Author	Winter, Andrew G. George, Sourvinos Allison, Simon J. Tosh, Kerrie Scott, Pamela H. Spandidos, Demetrios A. White, Robert J.
Copyright Year	2000
Abstract	Most transformed cells display abnormally high levels of RNA polymerase (pol) III transcripts. Although the full significance of this is unclear, it may be fundamental because healthy cells use two key tumor suppressors to restrain pol III activity. We present the first evidence that a pol III transcription factor is overexpressed in tumors. This factor, TFIIIC2, is a histone acetyltransferase that is required for synthesis of most pol III products, including tRNA and 5S rRNA. TFIIIC2 is a complex of five polypeptides, and mRNAs encoding each of these subunits are overexpressed in human ovarian carcinomas; this may explain the elevated TFIIIC2 activity that is found consistently in the tumors. Deregulation in these cancers is unlikely to be a secondary response to rapid proliferation, because there is little or no change in TFIIIC2 mRNA levels when actively cycling cells are compared with growth-arrested cells in culture. Using purified factors, we show that raising the level of TFIIIC2 is sufficient to stimulate pol III transcription in ovarian cell extracts. The data suggest that overexpression of TFIIIC2 contributes to the abnormal abundance of pol III transcripts in ovarian tumors.
Related Links	http://dx.doi.org/10.1073/pnas.230224097
Ending Page	12624
Page Count	6
Starting Page	12619
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	97
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2000-11-07
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.

Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TFIIIC) complex

Transcription termination factor La is also an initiation factor for RNA polymerase III.

Transcription termination factor La is also an initiation factor for RNA polymerase III.

The TATA-binding protein is a general transcription factor for RNA polymerase III

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RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human

The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes

Distinct roles of transcription factors TFIIIB and TFIIIC in RNA polymerase III transcription reinitiation

RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors

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RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors.

Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TFIIIC) complex

Transcription termination factor La is also an initiation factor for RNA polymerase III.

Transcription termination factor La is also an initiation factor for RNA polymerase III.

The TATA-binding protein is a general transcription factor for RNA polymerase III

RNA polymerase II-dependent transcription in trypanosomes is associated with a SNAP complex-like transcription factor

RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human

The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes

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RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors