NDLI: Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice

Content Provider	PubMed Central
Author	Reis, Ernane D. Roqué, Mercè Dansky, Hayes Fallon, John T. Badimon, Juan J. Carlos, Cordon-cardo Shiff, Steven J. Fisher, Edward A.
Copyright Year	2000
Abstract	Neointimal hyperplasia is a critical component of restenosis, a major complication of angioplasty and related therapeutic procedures. We studied the effects of hyperlipidemia and the nonsteroidal anti-inflammatory drugs, aspirin (acetyl-salicylic acid; ASA), and sulindac, on neointimal formation in a mouse femoral arterial injury model. At 2 months of age, normolipidemic, wild-type (WT), and hyperlipidemic, apolipoprotein E-deficient (apoE−/−) mice were divided into three treatment groups: Western-type diet (WD), WD + ASA (200 mg/kg food), and WD + sulindac (300 mg/kg food). After 1 week, mice underwent arterial injury and treatments were maintained for 4 weeks. Histomorphometry of the injured arteries showed striking effects of plasma cholesterol levels and drug treatment on neointimal hyperplasia. In the WD or WD + ASA groups, apoE−/− mice had twice the neointimal area than WT mice (≈30,000 vs. 13,000 μm2 per section; P < 0.0001). Compared with ASA or WD alone, sulindac treatment resulted in ≈70% (P = 0.0001) and 50% (P = 0.01) reductions in the neointimal area in apoE−/− and WT mice, respectively. ASA, at a dose sufficient to inhibit platelet aggregation, did not affect neointimal formation in mice of either genotype. Evidence of macrophages was noted in the lesions of apoE−/− mice in the WD and WD + ASA groups, but remarkably, none was detectable with sulindac treatment, despite hyperlipidemia, suggesting early steps in the response to injury were abrogated. These results demonstrate sulindac reduces neointimal formation in both normolipidemic and hyperlipidemic settings and raise the possibility that similar benefits may be obtained in patients undergoing angioplasty and related procedures.
Related Links	http://dx.doi.org/10.1073/pnas.210394497
Ending Page	12769
Page Count	6
Starting Page	12764
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	97
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2000-11-07
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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