NDLI: Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice

Content Provider	PubMed Central
Author	Sousa, Alexandra O. Mazzaccaro, Richard J. Russell, Robert G. Lee, Francis K. Turner, Oliver C. Hong, Seokmann Kaer, Luc Van Bloom, Barry R.
Copyright Year	2000
Abstract	A necessary role for cytotoxic T lymphocytes in protection against Mycobacterium tuberculosis (MTB) has been suggested by studies of the β2-microglobulin-deficient mouse, which is unable to present antigens through MHC class I and class I-like molecules and invariably succumbs early after infection. To identify the relative contributions of distinct putative MHC class I-dependent cell populations in protection against tuberculosis, we compared a variety of gene-disrupted mouse strains for susceptibility to MTB infection. Among the strains tested, the most susceptible mice, as measured by survival time and bacterial loads, were the β2-microglobulin−/−, followed by transporter associated with antigen processing deficient (TAP1−/−), CD8α−/−, perforin−/−, and CD1d−/− mice. These findings indicated that (i) CD8+ T cells contribute to protection against MTB, and their protective activity is only partially dependent on perforin; (ii) β2-microglobulin-dependent T cell populations distinct from CD8+ T cells also contribute to anti-MTB immunity; and (iii) protective immune mechanisms are predominantly TAP-dependent, although TAP-independent mechanisms also contribute to protection. Because CD1d-deficient animals were fully resistant to MTB, other TAP-independent mechanisms must contribute to protection. We suggest here that both classical and nonclassical MHC class I-restricted T cells, distinct from CD1d-restricted cells, may be involved in protective immune responses against tuberculosis.
Starting Page	4204
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	97
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2000-04-11
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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