NDLI: Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival

Content Provider	PubMed Central
Author	Meucci, Olimpia Alessandro, Fatatis Simen, Arthur A. Miller, Richard J.
Copyright Year	2000
Abstract	Recent in vitro and in vivo studies have shown that the chemokine fractalkine is widely expressed in the brain and localized principally to neurons. Central nervous system expression of CX3CR1, the only known receptor for fractalkine, has been demonstrated exclusively on microglia and astrocytes. Thus, it has been proposed that fractalkine regulates cellular communication between neurons (that produce fractalkine) and microglia (that express its receptor). Here we show, for the first time, that hippocampal neurons also express CX3CR1. Receptor activation by soluble fractalkine induces activation of the protein kinase Akt, a major component of prosurvival signaling pathways, and nuclear translocation of NF-κB, a downstream effector of Akt. Fractalkine protects hippocampal neurons from the neurotoxicity induced by the HIV-1 envelope protein gp120IIIB, an effect blocked by anti-CX3CR1 antibodies. Experiments with two different inhibitors of the phosphatidylinositol 3-kinase, a key enzyme in the activation of Akt, and with a phospholipid activator of Akt demonstrate that Akt activation is responsible for the neuroprotective effects of fractalkine. These data show that neuronal CX3CR1 receptors mediate the neurotrophic effects of fractalkine, suggesting that fractalkine and its receptor are involved in a complex network of both paracrine and autocrine interactions between neurons and glia.
Related Links	http://dx.doi.org/10.1073/pnas.090017497
Ending Page	8080
Page Count	6
Starting Page	8075
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	97
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2000-07-05
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging

CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD

Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb

ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

Differential Expression of Chemokine Receptors and their Roles in Cancer Imaging

Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state

Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival

Similar Documents

Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.

Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging

CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD

Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb

ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

Differential Expression of Chemokine Receptors and their Roles in Cancer Imaging

Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state

Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival