NDLI: pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120 E4F

Content Provider	PubMed Central
Author	Lluis, Fajas Paul, Conception Zugasti, Olivier Cam, Laurent Le Polanowska, Jolanta Eric, Fabbrizio Medema, René Vignais, Marie-luce Sardet, Claude
Copyright Year	2000
Abstract	The retinoblastoma protein pRB is involved in the transcriptional control of genes essential for cell cycle progression and differentiation. pRB interacts with different transcription factors and thereby modulates their activity by sequestration, corepression, or activation. We report that pRB, but not p107 and p130, binds to and facilitates repression by p120 E4F , a ubiquitously expressed GLI-Kruppel-related protein identified as a cellular target of E1A. The interaction involves two distinct regions of p120 E4F and the C-terminal part of pRB. In vivo pRB–p120 E4F complexes can only be detected in growth-arrested cells, and accordingly contain the hypophosphorylated form of pRB. Repression of an E4F-responsive promoter is strongly increased by combined expression of p120 E4F and pRB, which correlates with pRB-dependent enhancement of p120 E4F binding activity. Elevated levels of p120 E4F have been shown to block growth of mouse fibroblasts in G1. We find this requires pRB, because RB −/− fibroblasts are significantly less sensitive to excess p120 E4F .
Related Links	http://dx.doi.org/10.1073/pnas.130198397
Ending Page	7743
Page Count	6
Starting Page	7738
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	97
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2000-07-05
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.

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pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120 E4F

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pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.

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