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| Content Provider | PubMed Central |
|---|---|
| Author | Endoh, Takayuki |
| Copyright Year | 2006 |
| Abstract | The profile of opioid and cannabinoid receptors in neurons of the nucleus tractus solitarius (NTS) has been studied using the whole-cell configuration of the patch clamp technique. Experiments with selective agonists and antagonists of opioid, ORL and cannabinoid receptors indicated that μ-opioid, κ-opioid, ORL-1 and CB1, but not δ-opioid, receptors inhibit VDCCs in NTS. Application of [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO; μ-opioid receptor agonist), Orphanin FQ (ORL-1 receptor agonist) and WIN55,122 (CB1 receptor agonist) caused inhibition of I Ba in a concentration-dependent manner, with IC50's of 390 nM, 220 nM and 2.2 μ M, respectively. Intracellular dialysis of the Gi-protein antibody attenuated DAMGO-, Orphanin FQ- and WIN55,122-induced inhibition of I Ba. Both pretreatment with adenylate cyclase inhibitor and intracellular dialysis of the protein kinase A (PKA) inhibitor attenuated WIN55,122-induced inhibition of I Ba but not DAMGO- and Orphanin FQ-induced inhibition. Mainly N- and P/Q-type VDCCs were inhibited by both DAMGO and Orphanin FQ, while L-type VDCCs were inhibited by WIN55,122. These results suggest that μ- and κ-opioid receptors and ORL-1 receptor inhibit N- and P/Q-type VDCCs via Gα i-protein βγ subunits, whereas CB1 receptors inhibit L-type VDCCs via Gα i-proteins involving PKA in NTS. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0706623 |
| Ending Page | 401 |
| Page Count | 11 |
| Starting Page | 391 |
| File Format | |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 147 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2006-02-01 |
| Access Restriction | Open |
| Rights Holder | Nature Publishing Group |
| Subject Keyword | Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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