NDLI: Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node

Content Provider	PubMed Central
Author	Kreuzberg, Maria M. Schrickel, Jan W. Ghanem, Alexander Kim, Jung-sun Degen, Joachim Ulrike, Janssen-bienhold Thorsten, Lewalter Tiemann, Klaus Willecke, Klaus
Copyright Year	2006
Abstract	In the mammalian heart, gap junction channels between electrically coupled cardiomyocytes are necessary for impulse propagation and coordinated contraction of atria and ventricles. Recently, mouse connexin30.2 (Cx30.2) was shown to be expressed in the cardiac conduction system, predominantly in sinoatrial and atrioventricular (AV) nodes. The corresponding gap junctional channels expressed in HeLa cells exhibit the lowest unitary conductance (9 pS) of all connexin channels. Here we report that Cx30.2 slows down the propagation of excitation through the AV node. Mice expressing a LacZ reporter gene instead of the Cx30.2 coding region (Cx30.2LacZ/LacZ) exhibit a PQ interval that is ≈25% shorter than in WT littermates. By recording atrial, His, and ventricular signals with intracardiac electrodes, we show that this decrease is attributed to significantly accelerated conduction above the His bundle (atrial-His interval: 27.9 ± 5.1 ms in Cx30.2LacZ/LacZ versus 37.1 ± 4.1 ms in Cx30.2+/+ mice), whereas HV conduction is unaltered. Atrial stimulation revealed an elevated AV-nodal conduction capacity and faster ventricular response rates during induced episodes of atrial fibrillation in Cx30.2LacZ/LacZ mice. Our results show that Cx30.2 contributes to the slowdown of impulse propagation in the AV node and additionally limits the maximum number of beats conducted from atria to ventricles. Thus, it is likely to be involved in coordination of atrial and ventricular contraction and to fulfill a protective role toward pathophysiological states such as atrial tachyarrhythmias (e.g., atrial fibrillation) by preventing rapid conduction to the ventricles potentially associated with hemodynamic deterioration.
Related Links	http://dx.doi.org/10.1073/pnas.0508512103
Ending Page	5964
Page Count	6
Starting Page	5959
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	103
Language	English
Publisher	National Academy of Sciences
Publisher Date	2006-04-11
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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