NDLI: Mitigation strategies for pandemic influenza in the United States

Content Provider	PubMed Central
Author	Germann, Timothy C. Kadau, Kai Longini, Ira M. Macken, Catherine A.
Copyright Year	2006
Abstract	Recent human deaths due to infection by highly pathogenic (H5N1) avian influenza A virus have raised the specter of a devastating pandemic like that of 1917–1918, should this avian virus evolve to become readily transmissible among humans. We introduce and use a large-scale stochastic simulation model to investigate the spread of a pandemic strain of influenza virus through the U.S. population of 281 million individuals for R 0 (the basic reproductive number) from 1.6 to 2.4. We model the impact that a variety of levels and combinations of influenza antiviral agents, vaccines, and modified social mobility (including school closure and travel restrictions) have on the timing and magnitude of this spread. Our simulations demonstrate that, in a highly mobile population, restricting travel after an outbreak is detected is likely to delay slightly the time course of the outbreak without impacting the eventual number ill. For R 0 < 1.9, our model suggests that the rapid production and distribution of vaccines, even if poorly matched to circulating strains, could significantly slow disease spread and limit the number ill to <10% of the population, particularly if children are preferentially vaccinated. Alternatively, the aggressive deployment of several million courses of influenza antiviral agents in a targeted prophylaxis strategy may contain a nascent outbreak with low R 0, provided adequate contact tracing and distribution capacities exist. For higher R 0, we predict that multiple strategies in combination (involving both social and medical interventions) will be required to achieve similar limits on illness rates.
Related Links	http://dx.doi.org/10.1073/pnas.0601266103
Ending Page	5940
Page Count	6
Starting Page	5935
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	103
Language	English
Publisher	National Academy of Sciences
Publisher Date	2006-04-11
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mitigation strategies for pandemic influenza in the United States

Modeling targeted layered containment of an influenza pandemic in the United States

Strategies for Pandemic and Seasonal Influenza Vaccination of Schoolchildren in the United States

Influenza Pandemic Waves under Various Mitigation Strategies with 2009 H1N1 as a Case Study

Strategies for Pandemic and Seasonal Influenza Vaccination of Schoolchildren in the United States

Cost-Effectiveness of 2009 Pandemic Influenza A(H1N1) Vaccination in the United States

Rescinding Community Mitigation Strategies in an Influenza Pandemic

Economic analysis of pandemic influenza mitigation strategies for five pandemic severity categories

Identification of H2N3 influenza A viruses from swine in the United States

Mitigation strategies for pandemic influenza in the United States

Similar Documents

Mitigation strategies for pandemic influenza in the United States

Modeling targeted layered containment of an influenza pandemic in the United States

Strategies for Pandemic and Seasonal Influenza Vaccination of Schoolchildren in the United States

Influenza Pandemic Waves under Various Mitigation Strategies with 2009 H1N1 as a Case Study

Strategies for Pandemic and Seasonal Influenza Vaccination of Schoolchildren in the United States

Cost-Effectiveness of 2009 Pandemic Influenza A(H1N1) Vaccination in the United States

Rescinding Community Mitigation Strategies in an Influenza Pandemic

Economic analysis of pandemic influenza mitigation strategies for five pandemic severity categories

Identification of H2N3 influenza A viruses from swine in the United States

Mitigation strategies for pandemic influenza in the United States