NDLI: Understanding the Shape of Sickled Red Cells

Content Provider	PubMed Central
Author	Christoph, Garrott W. Hofrichter, James Eaton, William A.
Copyright Year	2005
Abstract	To understand the physical basis of the wide variety of shapes of deoxygenated red cells from patients with sickle cell anemia, we have measured the formation rate and volume distribution of the birefringent domains of hemoglobin S fibers. We find that the domain formation rate depends on the ∼80th power of the protein concentration, compared to ∼40th power for the concentration dependence of the reciprocal of the delay time that precedes fiber formation. These remarkably high concentration dependences, as well as the exponential distribution of domain volumes, can be explained by the previously proposed double nucleation model in which homogeneous nucleation of a single fiber triggers the formation of an entire domain via heterogeneous nucleation and growth. The enormous sensitivity of the domain formation rate to intracellular hemoglobin S concentration explains the variable cell morphology and why rapid polymerization results in cells that do not appear sickled at all.
Related Links	http://dx.doi.org/10.1529/biophysj.104.051250
Ending Page	1376
Page Count	6
Starting Page	1371
File Format	PDF
ISSN	00063495
e-ISSN	15420086
Journal	Biophysical Journal
Issue Number	2
Volume Number	88
Language	English
Publisher	Biophysical Society
Publisher Date	2005-02-01
Access Restriction	Open
Rights Holder	Biophysical Society
Subject Keyword	Biophysics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biophysics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS

Sickled hypochromic red blood cells.

The contribution of red blood cells to thrombin generation in sickle cell disease: meizothrombin generation on sickled red blood cells

Shape Memory of Human Red Blood Cells

Partially oxygenated sickled cells: sickle-shaped red cells found in circulating blood of patients with sickle cell disease.

Remodeling the shape of the skeleton in the intact red cell.

A Theory for the Shape of the Red Blood Cell

Shape change of sickled erythrocytes induced by pulsed rf electrical fields.

A new method to study shape recovery of red blood cells using multiple optical trapping.

Understanding the Shape of Sickled Red Cells

Similar Documents

THE SPECIFIC HEAT AND THE HEAT OF COMPRESSION OF HUMAN RED CELLS, SICKLED RED CELLS, AND PARACRYSTALLINE RAT RED CELLS

Sickled hypochromic red blood cells.

The contribution of red blood cells to thrombin generation in sickle cell disease: meizothrombin generation on sickled red blood cells

Shape Memory of Human Red Blood Cells

Partially oxygenated sickled cells: sickle-shaped red cells found in circulating blood of patients with sickle cell disease.

Remodeling the shape of the skeleton in the intact red cell.

A Theory for the Shape of the Red Blood Cell

Shape change of sickled erythrocytes induced by pulsed rf electrical fields.

A new method to study shape recovery of red blood cells using multiple optical trapping.

Understanding the Shape of Sickled Red Cells