NDLI: Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay

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Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology

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Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER)

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Test No. 476: In vitro Mammalian Cell Gene Mutation Test

Test No. 483: Mammalian Spermatogonial Chromosome Aberration Test

Test No. 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo

Test No. 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure

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Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells

Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay

Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay

Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro

Test No. 484: Genetic Toxicology: Mouse Spot Test

Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay

Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test

Test No. 415: One-Generation Reproduction Toxicity Study

Test No. 410: Repeated Dose Dermal Toxicity: 21/28-day Study

Test No. 411: Subchronic Dermal Toxicity: 90-day Study

Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay

Content Provider	OECD iLibrary
Organization	OECD
Abstract	The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations. Carriers of translocations and XO-females show reduced fertility which is used to select first generation progeny for cytogenetic analysis. Translocations are cytogenetically observed in meiotic cells at diakinesis metaphase I of male individuals. The test is usually performed by analysis of male first generation progeny. About 500 first generation males per dose level are required. One dose level is tested, usually the highest dose associated with the production of minimal toxic effects, and administered by oral intubation or intraperitoneal injection. A single administration of the test substance or the administration of the test substance on 7 days/week for 35 days, are possible. The test substance can be solid, liquid, vapour or gaseous. For translocation heterozygosity one of two possible methods is used: fertility testing of first generation progeny; or cytogenetic analysis of all male first generation progeny are possible. A test substance producing neither a statistically significant increase in the number of translocations observed for at least one test point, nor a statistically significant, dose-related, increase in the number of translocations observed, is considered non-mutagenic in this system.
Page Count	6
ISSN	20745788
e-ISBN	9789264071506
Language	English
Publisher	OECD Publishing
Publisher Date	1986-10-23
Access Restriction	Open
Subject Keyword	Environment
Content Type	Text
Resource Type	Book

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