NDLI: Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies

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Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene

Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Test No. 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage

Test No. 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity

Test No. 404: Acute Dermal Irritation/Corrosion

Test No. 421: Reproduction/Developmental Toxicity Screening Test

Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test

Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)

Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method

Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion

Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists

Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes

Test No. 478: Rodent Dominant Lethal Test

Test No. 483: Mammalian Spermatogonial Chromosomal Aberration Test

Test No. 442C: In Chemico Skin Sensitisation. Direct Peptide Reactivity Assay (DPRA).

Test No. 442D: In Vitro Skin Sensitisation. ARE-Nrf2 Luciferase Test Method.

Test No. 489: In Vivo Mammalian Alkaline Comet Assay

Test No. 473: In Vitro Mammalian Chromosomal Aberration Test

Test No. 474: Mammalian Erythrocyte Micronucleus Test

Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test

Test No. 487: In Vitro Mammalian Cell Micronucleus Test

Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Test No. 439: In Vitro Skin Irritation - Reconstructed Human Epidermis Test Method

Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

Test No. 405: Acute Eye Irritation/Corrosion

Test No. 443: Extended One-Generation Reproductive Toxicity Study

Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists

Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists

Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants

Test No. 456: H295R Steroidogenesis Assay

Test No. 417: Toxicokinetics

Test No. 429: Skin Sensitisation. Local Lymph Node Assay.

Test No. 439: In Vitro Skin Irritation. Reconstructed Human Epidermis Test Method.

Test No. 442A: Skin Sensitization. Local Lymph Node Assay: DA.

Test No. 442B: Skin Sensitization. Local Lymph Node Assay: BrdU-ELISA.

Test No. 403: Acute Inhalation Toxicity

Test No. 412: Subacute Inhalation Toxicity: 28-Day Study

Test No. 413: Subchronic Inhalation Toxicity: 90-day Study

Test No. 451: Carcinogenicity Studies

Test No. 452: Chronic Toxicity Studies

Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies

Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method

Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants

Test No. 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants

Test No. 441: Hershberger Bioassay in Rats. A Short-term Screening Assay for (Anti)Androgenic Properties.

Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals

Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents

Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure

Test No. 426: Developmental Neurotoxicity Study

Test No. 440: Uterotrophic Bioassay in Rodents. A short-term screening test for oestrogenic properties.

Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology

Test No. 427: Skin Absorption: In Vivo Method

Test No. 428: Skin Absorption: In Vitro Method

Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER)

Test No. 431: In Vitro Skin Corrosion: Human Skin Model Test

Test No. 432: In Vitro 3T3 NRU Phototoxicity Test

Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure

Test No. 423: Acute Oral toxicity - Acute Toxic Class Method

Test No. 414: Prenatal Development Toxicity Study

Test No. 416: Two-Generation Reproduction Toxicity

Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents

Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents

Test No. 424: Neurotoxicity Study in Rodents

Test No. 471: Bacterial Reverse Mutation Test

Test No. 473: In vitro Mammalian Chromosome Aberration Test

Test No. 475: Mammalian Bone Marrow Chromosome Aberration Test

Test No. 476: In vitro Mammalian Cell Gene Mutation Test

Test No. 483: Mammalian Spermatogonial Chromosome Aberration Test

Test No. 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo

Test No. 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure

Test No. 419: Delayed Neurotoxicity of Organophosphorus Substances: 28-day Repeated Dose Study

Test No. 406: Skin Sensitisation

Test No. 401: Acute Oral Toxicity

Test No. 402: Acute Dermal Toxicity

Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells

Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay

Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay

Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro

Test No. 484: Genetic Toxicology: Mouse Spot Test

Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay

Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test

Test No. 415: One-Generation Reproduction Toxicity Study

Test No. 410: Repeated Dose Dermal Toxicity: 21/28-day Study

Test No. 411: Subchronic Dermal Toxicity: 90-day Study

Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies

Content Provider	OECD iLibrary
Organization	OECD
Abstract	The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for this study. For rodents, each dose group and concurrent control group intended for the carcinogenicity phase of the study should contain at least 50 animals of each sex, while for the chronic toxicity phase of the study should contain at least 10 animals of each sex. At least three dose levels should be used, in addition to the concurrent control group for both the chronic toxicity phase and the carcinogenicity phase of the study. The three main routes of administration are oral, dermal, and inhalation. The Test Guideline focuses on the oral route of administration. The period of dosing and duration of the study is normally 12 months for the chronic phase, and 24 months for the carcinogenicity phase. The study report should include: measurements (weighing) and regular detailed observations (haematological examination, urinalysis, clinical chemistry), as well as necropsy procedures and histopathology. All these observations permit the detection of neoplastic effects and a determination of carcinogenic potential as well as the general toxicity.
Page Count	20
ISSN	20745788
e-ISBN	9789264071223
Language	English
Publisher	OECD Publishing
Publisher Date	2009-09-08
Access Restriction	Open
Subject Keyword	Environment
Content Type	Text
Resource Type	Book

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