NDLI: Characterization of Dental Pulp Stem Cells Response to Bone Substitutes Biomaterials in Dentistry

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Characterization of Dental Pulp Stem Cells Response to Bone Substitutes Biomaterials in Dentistry

Content Provider	MDPI
Author	Tinco, Rosanna Di Consolo, Ugo Pisciotta, Alessandra Orlandi, Giulia Bertani, Giulia Nasi, Milena Bertacchini, Jessika Carnevale, Gianluca
Copyright Year	2022
Description	Bone substitute biomaterials (BSBs) represent a promising alternative to bone autografts, due to their biocompatibility, osteoconduction, slow resorption rates, and the ability to define and maintain volume for bone gain in dentistry. Many biomaterials are tailored to provide structural and biological support for bone regeneration, and allow the migration of bone-forming cells into the bone defect. Neural crest-derived stem cells isolated from human dental pulp (hDPSCs) represent a suitable stem cell source to study the biological effects of BSBs on osteoprogenitor cells involved in the physiological bone regenerative processes. This study aimed to evaluate how three different BSBs affect the stem cell properties, osteogenic differentiation, and inflammatory properties of hDPSCs. Our data highlight that BSBs do not alter cell proliferation and stemness markers expression, nor induce any inflammatory responses. Bone metabolism data show that hDPSCs exposed to the three BSBs distinctively secrete the factors supporting osteoblast activity and osteoclast activity. Our data indicate that (i) hDPSCs are a suitable stem cell source to study the effects of BSBs, and that (ii) the formulation of BSBs may condition the biological properties of stem cells, suggesting their versatile suitability to different dentistry applications.
Starting Page	2223
e-ISSN	20734360
DOI	10.3390/polym14112223
Journal	Polymers
Issue Number	11
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-05-30
Access Restriction	Open
Subject Keyword	Polymers Dentistry and Oral Surgery Human Dental Pulp Stem Cells Neural Crest Osteogenic Differentiation
Content Type	Text
Resource Type	Article

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