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Extended-Spectrum-β-Lactamase- and AmpC-Producing Escherichia coli in Domestic Dogs: Spread, Characterisation and Associated Risk Factors
| Content Provider | MDPI |
|---|---|
| Author | Formenti, Nicoletta Grassi, Andrea Parisio, Giovanni Romeo, Claudia Guarneri, Flavia Birbes, Laura Pitozzi, Alessandra Scali, Federico Maisano, Antonio Marco Boniotti, Maria Beatrice Pasquali, Paolo Alborali, Giovanni Loris |
| Copyright Year | 2021 |
| Description | In veterinary medicine, the issue of antimicrobial resistance was mainly addressed in food-producing animals (although companion animals also deserve attention). Indeed, these species may be reservoir of resistant microorganisms, such as extended-spectrum β-lactamase and AmpC (ESBL/AmpC)-producing bacteria. Dogs in particular may transmit them to close-contact humans. Overall 266 faecal samples of healthy dogs were microbiologically and molecularly analyzed to investigate ESBL/AmpC-producing Escherichia coli and the effects of host and environmental factors on their spread. A prevalence of 25.9% of ESBL/AmpC-producing E. coli, supported by $bla_{CTX-M}$ (79.7%), $bla_{TEM}$ (47.8%), $bla_{CMY}$ (13%), and $bla_{SHV}$ (5.8%) gene detection, emerged. Dogs frequenting extra-urban environments showed significantly higher odds of being positive to ESBL/AmpC E. coli (30.2%) compared to urban dogs (16.7%) identifying the environment as a risk factor. About 88.4% of isolates were resistant to cephalosporins, 8.7% to cephalosporins and carbapenems, and 2.9% to cephalosporins, carbapenems, and penicillins. ESBL/AmpC-producing E. coli expressing $bla_{CMY}$ were significantly more resistant to cefoxitin, cefotaxime/clavulanic acid and ceftazidime/clavulanic acid, highlighting its negative effects. Our results suggest the role of domestic dogs as a maintenance host of ESBL/AmpC-producing E. coli leading to a constant health monitoring. The recorded resistances to carbapenems implies attention and further investigations. |
| Starting Page | 1251 |
| e-ISSN | 20796382 |
| DOI | 10.3390/antibiotics10101251 |
| Journal | Antibiotics |
| Issue Number | 10 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-10-15 |
| Access Restriction | Open |
| Subject Keyword | Antibiotics Microbiology Extra-urban Environments Blacmy Cefotaxime/clavulanic Acid Ceftazidime/clavulanic Acid Blactx-m Cefoxitin Multidrug Resistance (mdr) Carbapenems |
| Content Type | Text |
| Resource Type | Article |
