NDLI: Prevalence of plasmid-mediated AmpC β-lactamase-producing Escherichia coli and spread of the ST131 clone among extended-spectrum β-lactamase-producing E. coli in Japan.

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Prevalence of plasmid-mediated AmpC β-lactamase-producing Escherichia coli and spread of the ST131 clone among extended-spectrum β-lactamase-producing E. coli in Japan.

Content Provider	Semantic Scholar
Author	Matsumura, Yasufumi Yamamoto, Masaki Higuchi, Takeshi Komori, Toshiaki Tsuboi, Fusayuki Hayashi, Akihiko Sugimoto, Yoshihisa Hotta, Gou Matsushima, Aki Nagao, Miki Takakura, Shunji Ichiyama, Satoshi
Copyright Year	2012
Abstract	In 2010, a total of 1327 clinical Escherichia coli isolates from five hospitals in the Kyoto and Shiga regions of Japan were analysed by PCR. The prevalences of plasmid-mediated AmpC β-lactamase (pAmpC)-producers, extended-spectrum β-lactamase (ESBL)-producers and co-producers of pAmpC and ESBL were 1.7%, 9.7% and 0.3%, respectively. Less than one-half of the pAmpC-producers were reported to be resistant to third-generation cephalosporins, cephamycins and β-lactam/β-lactam inhibitors using the old 2009 Clinical and Laboratory Standards Institute (CLSI) breakpoints. CMY-2 was the most prevalent pAmpC type (95%), and CTX-M-14 (38%), CTX-M-15 (26%) and CTX-M-27 (19%) were the most prevalent ESBL types. The worldwide O25b-ST131-B2 clone accounted for 11% of pAmpC-producers and 41% of ESBL-producers. The O25b-ST131-B2 clone was characterised by a CTX-M-27- or CTX-M-15-type ESBL and ciprofloxacin-non-susceptibility with quadruple mutations in the quinolone resistance-determining regions (S83L and D87N in GyrA and S80I and E84V in ParC). A significant proportion of pAmpC-producers and the O25b-ST131-B2 clone were found in Japan by a recent regional surveillance programme.
File Format	PDF HTM / HTML
DOI	10.1016/j.ijantimicag.2012.04.013
Alternate Webpage(s)	https://core.ac.uk/download/pdf/39303641.pdf
Alternate Webpage(s)	https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/178036/1/j.ijantimicag.2012.04.013.pdf
PubMed reference number	22743014
Alternate Webpage(s)	https://doi.org/10.1016/j.ijantimicag.2012.04.013
Journal	Medline
Volume Number	40
Issue Number	2
Journal	International journal of antimicrobial agents
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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