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Usefulness of PET/CT with$ ^{18}$F-FDG in Patients with Differentiated Thyroid Carcinoma after Radioiodine Therapy: An Italian Multicenter Study
| Content Provider | MDPI |
|---|---|
| Author | Filippi, Luca Frantellizzi, Viviana Monari, Fabio Rizzini, Elisa Lodi Tabacchi, Elena Pirisino, Riccardo Marongiu, Andrea Nuvoli, Susanna Bagni, Oreste Vincentis, Giuseppe De Schillaci, Orazio Spanu, Angela |
| Copyright Year | 2021 |
| Description | Background: our aim was to assess the diagnostic performance and clinical impact of$ ^{18}$F-FDG PET/CT in patients with differentiated thyroid carcinoma (DTC), previously treated with surgery and radioiodine therapy (RAI). Methods: patients subjected to$ ^{18}$F-FDG PET/CT for suspected DTC recurrence in three Italian nuclear medicine units were evaluated. Two different clinical settings were identified: clinical setting 1 included patients (n = 40) that were enrolled according to the American Thyroid Association guidelines (i.e., negative$ ^{131}$1-WBS and Tg level > 10 ng/mL); and clinical setting 2, that encompassed subjects (n = 26) with serum Tg ≤ 10 ng/mL but morphological findings suspected of relapse. PET/CT’s impact was scored as significant if it provided an indication for surgery, or led to a novel therapeutic decision. Results: In total, 51/66 patients (77.3%) were$ ^{18}$F-FDG positive, while 15 (22.7%) were negative. PET/CT showed an overall sensitivity and specificity of 84.4% and 75%, respectively. Sensitivity was higher in clinical setting 1 (89.1%) as compared to clinical setting 2 (76.1%), although this difference was not statistically significant (p = 0.83). PET/CT influenced clinical management in 28 cases (42.4%), without a significant difference between the 2 groups of patients (p = 0.6). Conclusions: our preliminary data, although limited by the retrospective nature of the study and possible selection bias, suggest that$ ^{18}$F-FDG PET/CT may be utilized for the detection of DTC recurrence in different clinical settings, with a meaningful impact on clinical management. |
| Starting Page | 1264 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics11071264 |
| Journal | Diagnostics |
| Issue Number | 7 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-14 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Oncology 18f-fdg Positron Emission Computed Tomography Differentiated Thyroid Carcinoma Precision Medicine |
| Content Type | Text |
| Resource Type | Article |
