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Differences between $[^{18}$F]FLT and $[^{18}$F]FDG Uptake in PET/CT Imaging in CC Depend on Vaginal Bacteriology
| Content Provider | MDPI |
|---|---|
| Author | Paulina, Cegła Witold, Cholewiński Burchardt, Ewa Warenczak-Florczak, Zaneta Piotrowski, Adam Cybulski, Zefiryn Burchardt, Wojciech Roszak, Andrzej |
| Copyright Year | 2021 |
| Description | This study aims to investigate if vaginal bacteriology obtained prior to treatment influences the 3′-deoxy-3 18F-fluorothymidine (FLT) $[^{18}$F]FLT and $2-deoxy-2-[^{18}$F]fluoro-d-glucose $(2-[^{18}$F]FDG) $[^{18}$F]FDG parameters in positron emission tomography (PET/CT) in cervical cancer (CC) patients. Methods: Retrospective analysis was performed on 39 women with locally advanced histologically confirmed cervical cancer who underwent dual tracer PET/CT examinations. The $[^{18}$F]FLT and $[^{18}$F]FDG PET parameters in the primary tumor, including SUVmax, SUVmean, MTV, heterogeneity, before radiotherapy (RT) were analyzed, depending on the bacteriology. The p-values < 0.05 were considered statistically significant. Results: In the vaginal and/or cervical smears, there were 27 (79.4%) positive results. In seven (20.6%) cases, no opportunistic pathogen growth was observed (No Bacteria Group). In positive bacteriology, eleven (32%) Gram-negative bacilli (Bacteria group 2) and fifteen (44%) Gram-positive bacteria (Bacteria group 1) were detected. Five patients with unknown results were excluded from the analysis. Data analysis shows a statistically significant difference between the $SUV_{max}$, and $SUV_{min}$ values for three independent groups for the $[^{18}$F]FLT. Conclusions: The lowest values of $SUV_{max}$ and $SUV_{min}$ for $[^{18}$F]FLT are registered in Gram-negative bacteria, higher are in Gram-positive, and the absence of bacteria causes the highest $[^{18}$F]FLT values. |
| Starting Page | 70 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics12010070 |
| Journal | Diagnostics |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-29 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Oncology 18f-fluorothymidine ([18f]flt) 18f-fluoro-d-glucose ([18f]fdg) Positron Emission Tomography Computed Tomography Vaginal Bacteriology Cervical Cancer |
| Content Type | Text |
| Resource Type | Article |
