Relations Between Pathological Markers and Radioiodine Scan and (18)F-FDG PET/CT Findings in Papillary Thyroid Cancer Patients With Recurrent Cervical Nodal Metastases.

Content Provider	Europe PMC
Author	Lee, Jeong Won Min, Hye Sook Lee, Sang Mi Kwon, Hyun Woo Chung, June-Key
Abstract	Purpose The aim of this study was to investigate relationships between the immunohistochemical results and radioiodine scan and 18F-FDG PET findings in papillary thyroid cancer (PTC) patients with recurrent cervical nodal metastases. Methods A total of 46 PTC patients who had undergone a radioiodine scan and/or 18F-FDG PET/CT and a subsequent operation on recurrent cervical lymph nodes were enrolled. Twenty-seven patients underwent 18F-FDG PET/CT, 8 underwent radioiodine scans, and 11 underwent both scans. In all surgical specimens, the immunoexpressions of thyroglobulin (Tg), sodium-iodide symporter (NIS), glucose transporter 1 (Glut-1), and somatostatin receptor 1 and 2A (SSTR1 and SSTR2A) were assessed, and associations between these expressions and radioiodine scan and 18F-FDG PET findings were evaluated. Results Of the 38 patients who underwent 18F-FDG PET/CT, all patients with weak Tg expression had positive 18F-FDG uptake, while only 45 % of the patients with moderate or strong Tg expression showed positive uptake (p = 0.01). The proportion of patients with positive 18F-FDG uptake increased as the degree of Glut-1 expression with luminal accentuation increased. Of the 19 patients who underwent a radioiodine scan, the proportion with positive radioiodine uptake was greater among patients with strong NIS and SSTR2A expression than among patients expressing these markers at weak levels (p = 0.04 for all). All three patients with weak Tg expression were negative for radioiodine uptake. Conclusion The 18F-FDG uptakes of recurrent cervical nodes are related to strong Glut-1 expression with luminal accentuation and weak Tg expression, whereas radioiodine uptake is related to the strong expressions of NIS and SSTR2A.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4463869&blobtype=pdf
ISSN	18693474
Volume Number	49
DOI	10.1007/s13139-015-0324-6
PubMed Central reference number	PMC4463869
Issue Number	2
PubMed reference number	26085858
Journal	Nuclear Medicine and Molecular Imaging [Nucl Med Mol Imaging]
e-ISSN	18693482
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-02-13
Publisher Place	Berlin/Heidelberg
Access Restriction	Open
Rights License	© Korean Society of Nuclear Medicine 2015
Subject Keyword	Thyroid cancer 18F-fluorodeoxyglucose Positron emission tomography Radioiodine
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging