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SARS-CoV-2 IgG Antibodies Seroprevalence and Sera Neutralizing Activity in MEXICO: A National Cross-Sectional Study during 2020
| Content Provider | MDPI |
|---|---|
| Author | Jos, é Muñoz-Medina Concepci, ón Grajales-Muñiz Constantino, López-Macías Irma, Monroy-Muñoz Joaqu, ín González-Ibarra Cesar, González-Bonilla Salas-Lais, Angel Fernandes-Matano, Larissa Coy-Arechavaleta, Andrea Santos Palomec-Nava, Iliana Duque-Molina, Célida Madera-Sandoval, Ruth Rivero-Arredondo, Vanessa Alvarado-Yaah, Julio Rojas-Mendoza, Teresita Santacruz-Tinoco, Clara Borja-Aburto, Víctor |
| Copyright Year | 2021 |
| Description | Until recently, the incidence of COVID-19 was primarily estimated using molecular diagnostic methods. However, the number of cases is vastly underreported using these methods. Seroprevalence studies estimate cumulative infection incidences and allow monitoring of transmission dynamics, and the presence of neutralizing antibodies in the population. In February 2020, the Mexican Social Security Institute began conducting anonymous unrelated sampling of residual sera from specimens across the country, excluding patients with fever within the previous two weeks and/or patients with an acute respiratory infection. Sampling was carried out weekly and began 17 days before Mexico’s first officially confirmed case. The 24,273 sera obtained were analyzed by chemiluminescent-linked immunosorbent assay (CLIA) IgG S1/S2 and, later, positive cases using this technique were also analyzed to determine the rate of neutralization using the enzyme-linked immunosorbent assay (ELISA). We identified 40 CLIA IgG positive cases before the first official report of SARS-CoV-2 infection in Mexico. The national seroprevalence was 3.5% in February and 33.5% in December. Neutralizing activity among IgG positives patients during overall study period was 86.1%. The extent of the SARS-CoV-2 infection in Mexico is 21 times higher than that reported by molecular techniques. Although the general population is still far from achieving herd immunity, epidemiological indicators should be re-estimated based on serological studies of this type. |
| Starting Page | 850 |
| e-ISSN | 20762607 |
| DOI | 10.3390/microorganisms9040850 |
| Journal | Microorganisms |
| Issue Number | 4 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-15 |
| Access Restriction | Open |
| Subject Keyword | Microorganisms Microbiology Tropical Medicine Covid-19 Herd Immunity Serology Antibody Neutralization Clinical Laboratory Blood Bank Clia Elisa |
| Content Type | Text |
| Resource Type | Article |
