NDLI: Risk Factors, Diagnosis, and Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease

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Risk Factors, Diagnosis, and Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease

Content Provider	MDPI
Author	Stefano, Bibbò Vecchio, Livio Enrico Del Fiorani, Marcello Tohumcu, Ege Porcari, Serena Mele, Maria Cristina Pizzoferrato, Marco Gasbarrini, Antonio Cammarota, Giovanni Ianiro, Gianluca
Copyright Year	2022
Description	Clostridioides difficile infection (CDI) and inflammatory bowel disease (IBD) are two pathologies that share a bidirectional causal nexus, as CDI is known to have an aggravating effect on IBD and IBD is a known risk factor for CDI. The colonic involvement in IBD not only renders the host more prone to an initial CDI development but also to further recurrences. Furthermore, IBD flares, which are predominantly set off by a CDI, not only create a need for therapy escalation but also prolong hospital stay. For these reasons, adequate and comprehensive management of CDI is of paramount importance in patients with IBD. Microbiological diagnosis, correct evaluation of clinical status, and consideration of different treatment options (from antibiotics and fecal microbiota transplantation to monoclonal antibodies) carry pivotal importance. Thus, the aim of this article is to review the risk factors, diagnosis, and management of CDI in patients with IBD.
Starting Page	1315
e-ISSN	20762607
DOI	10.3390/microorganisms10071315
Journal	Microorganisms
Issue Number	7
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2022-06-29
Access Restriction	Open
Subject Keyword	Microorganisms Anesthesiology Clostridioides Difficile Inflammatory Bowel Disease Crohn's Disease Ulcerative Colitis Fecal Microbiota Transplantation
Content Type	Text
Resource Type	Article

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