Loading...
Please wait, while we are loading the content...
Similar Documents
Treatment of Recurrent Clostridioides difficile Infection Using Fecal Microbiota Transplantation in Iranian Patients with Underlying Inflammatory Bowel Disease
| Content Provider | Scilit |
|---|---|
| Author | Azimirad, Masoumeh Yadegar, Abbas Gholami, Fatemeh Shahrokh, Shabnam Aghdaei, Hamid Asadzadeh Ianiro, Gianluca Suzuki, Hidekazu Cammarota, Giovanni Zali, Mohammad Reza |
| Copyright Year | 2020 |
| Description | Purpose: Fecal microbiota transplantation (FMT) is an effective treatment option for patients with recurrent Clostridioides difficile infection (rCDI). However, there is a paucity of evidence regarding its efficacy and safety in patients with rCDI and concurrent inflammatory bowel disease (IBD). Here, we present a single-center experience of FMT for treatment of rCDI in Iranian patients with IBD. Patients and Methods: Eight patients with established IBD (7 with ulcerative colitis and 1 with Crohn's disease) who underwent at least one FMT via colonoscopy for treatment of rCDI were enrolled in this study. Demographics, pre-FMT and post-FMT IBD activity, efficacy for rCDI and adverse events (AEs) were assessed during a 6-month follow-up period. All patients had experienced 3 episodes of rCDI and were refractory to conventional therapies with metronidazole and vancomycin. Primary cure and secondary cure rates were assessed after FMT treatments. Results: A total of 10 FMTs were performed via colonoscopy in 8 patients (6/8; 75% men) with a median age of 35 years (range: 22– 60). Two patients received a second FMT. Overall, the primary and secondary cure rates were 75% and 100%, respectively. Two patients developed CPE-producing C. perfringens diagnoses after second FMTs. There were no other AEs, and no patient experienced IBD flare. Conclusion: We demonstrated that FMT appears to be an effective, safe and rational therapeutic alternative for resolution of rCDI in patients with underlying IBD. Furthermore, we suggest implementing the CPE-producing C. perfringens testing in the screening of FMT donors. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509309/pdf https://www.dovepress.com/getfile.php?fileID=61586 |
| Ending Page | 570 |
| Page Count | 8 |
| Starting Page | 563 |
| ISSN | 11787031 |
| e-ISSN | 11787031 |
| DOI | 10.2147/jir.s265520 |
| Journal | Journal of inflammation research |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-09-01 |
| Access Restriction | Open |
| Subject Keyword | Surgery Fecal Microbiota Transplantation Recurrent Clostridioides Difficile Infection Inflammatory Bowel Disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
