Epidemiology, Diagnosis, and Management of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease.

Content Provider	Scilit
Author	Rao, Krishna Higgins, Peter D. R.
Copyright Year	2016
Description	Journal: Inflammatory Bowel Diseases Clostridium difficile infection (CDI) is a major source of morbidity and mortality for the U.S. health care system and frequently complicates the course of inflammatory bowel disease (IBD). Patients with IBD are more likely to be colonized with C. difficile and develop active infection than the general population. They are also more likely to have severe CDI and develop subsequent complications such as IBD flare, colectomy, or death. Even after successful initial treatment and recovery, recurrent CDI is common. Management of CDI in IBD is fraught with diagnostic and therapeutic challenges because the clinical presentations of CDI and IBD flare have considerable overlap. Fecal microbiota transplantation can be successful in curing recurrent CDI when other treatments have failed, but may also trigger IBD flare and this warrants caution. New experimental treatments including vaccines, monoclonal antibodies, and nontoxigenic strains of C. difficile offer promise but are not yet available for clinicians. A better understanding of the complex relationship between the gut microbiota, CDI, and IBD is needed.
Related Links	http://pdfs.journals.lww.com/ibdjournal/2016/07000/Epidemiology,_Diagnosis,_and_Management_of.25.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1506297975877;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdFjgCJ8jBy+xQ4EOiUPiPq/huqj0BlK/6vu2x6kqKf+Y=;hash|Rg8LFhb9kmFHYq0u5mOQTw== https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911291/pdf https://academic.oup.com/ibdjournal/article-pdf/22/7/1744/23404219/ibd1744.pdf
ISSN	10780998
e-ISSN	15364844
DOI	10.1097/MIB.0000000000000793
Journal	Inflammatory Bowel Diseases
Issue Number	7
Volume Number	22
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2016-07-01
Access Restriction	Open
Subject Keyword	Journal: Inflammatory Bowel Diseases Infectious Diseases Ulcerative Colitis Crohn's Disease Inflammatory Bowel Disease Clostridium Difficile
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Gastroenterology