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Prognostic Value of C-Reactive Protein to Lymphocyte Ratio (CLR) in Emergency Department Patients with SARS-CoV-2 Infection
| Content Provider | MDPI |
|---|---|
| Author | Lise, Bérard L.R), C. R. E. M. S. Network (Clinical Research in Emergency Medicine and Sepsis) (C on behalf of C. R. E. M. S. Network Research in Emergency Medicine and Sepsis) (C L.R) Tonduangu, Ndenga Borgne, Pierrick Le Lefebvre, François Alame, Karine Gottwalles, Yannick Cipolat, Lauriane Gennai, Stéphane Bilbault, Pascal Lavoignet, Charles-Eric Vuillaume, Laure Abensur |
| Copyright Year | 2021 |
| Description | (1) Introduction: According to recent studies, the ratio of C-reactive-protein to lymphocyte is more sensitive and specific than other biomarkers associated to systemic inflammatory processes. This study aimed to determine the prognostic value of CLR on COVID-19 severity and mortality at emergency department (ED) admission. (2) Methods: Between 1 March and 30 April 2020, we carried out a multicenter and retrospective study in six major hospitals of northeast France. The cohort was composed of patients hospitalized for a confirmed diagnosis of moderate to severe COVID-19. (3) Results: A total of 1,035 patients were included in this study. Factors associated with infection severity were the CLR (OR: 1.001, CI 95%: (1.000–1.002), p = 0.012), and the lymphocyte level (OR: 1.951, CI 95%: (1.024–3.717), p = 0.042). In multivariate analysis, the only biochemical factor significantly associated with mortality was lymphocyte rate (OR: 2.308, CI 95%: (1.286–4.141), p = 0.005). The best threshold of CLR to predict the severity of infection was 78.3 (sensitivity 79%; specificity 47%), and to predict mortality, was 159.5 (sensitivity 48%; specificity 70%). (4) Conclusion: The CLR at admission to the ED could be a helpful prognostic biomarker in the early screening and prediction of the severity and mortality associated with SARS-CoV-2 infection. |
| Starting Page | 1274 |
| e-ISSN | 20754426 |
| DOI | 10.3390/jpm11121274 |
| Journal | Journal of Personalized Medicine |
| Issue Number | 12 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-02 |
| Access Restriction | Open |
| Subject Keyword | Journal of Personalized Medicine Emergency Medicine Covid-19 Clr Severity Mortality |
| Content Type | Text |
| Resource Type | Article |
