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Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection
| Content Provider | MDPI |
|---|---|
| Author | Simon, Noemi Jauslin, Andrea Rueegg, Marco Twerenbold, Raphael Lampart, Maurin Osswald, Stefan Bassetti, Stefano Tschudin-Sutter, Sarah Siegemund, Martin Nickel, Christian Bingisser, Roland |
| Copyright Year | 2021 |
| Description | Older age and frailty are predictors of adverse outcomes in patients with COVID-19. In emergency medicine, patients do not present with the diagnosis, but with suspicion of COVID-19. The aim of this study was to assess the association of frailty and age with death or admission to intensive care in patients with suspected COVID-19. This single-centre prospective cohort study was performed in the Emergency Department of a tertiary care hospital. Patients, 65 years and older, with suspected COVID-19 presenting to the Emergency Department during the first wave of the pandemic were consecutively enrolled. All patients underwent nasopharyngeal SARS-CoV-2 PCR swab tests. Patients with a Clinical Frailty Scale (CFS) > 4, were considered to be frail. Associations between age, gender, frailty, and COVID-19 status with the composite adverse outcome of 30-day-intensive-care-admission and/or 30-day-mortality were tested. In the 372 patients analysed, the median age was 77 years, 154 (41.4%) were women, 44 (11.8%) were COVID-19-positive, and 125 (33.6%) were frail. The worst outcome was seen in frail COVID-19-patients with six (66.7%) adverse outcomes. Frailty (CFS > 4) and COVID-19-positivity were associated with an adverse outcome after adjustment for age and gender (frailty: OR 5.01, CI 2.56–10.17, p < 0.001; COVID-19: OR 3.47, CI 1.48–7.89, p = 0.003). Frailty was strongly associated with adverse outcomes and outperformed age as a predictor in emergency patients with suspected COVID-19. |
| Starting Page | 2472 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm10112472 |
| Journal | Journal of clinical medicine |
| Issue Number | 11 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-02 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Emergency Medicine Age Frailty Covid-19 Sars-cov-2 Mortality Intensive Care Emergency Department |
| Content Type | Text |
| Resource Type | Article |
