NDLI: Platelet-to-Lymphocyte Ratio (PLR) Is Not a Predicting Marker of Severity but of Mortality in COVID-19 Patients Admitted to the Emergency Department: A Retrospective Multicenter Study

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Platelet-to-Lymphocyte Ratio (PLR) Is Not a Predicting Marker of Severity but of Mortality in COVID-19 Patients Admitted to the Emergency Department: A Retrospective Multicenter Study

Content Provider	MDPI
Author	Simon, Paul Borgne, Pierrick Le Lefevbre, François Cipolat, Lauriane Remillon, Aline Dib, Camille Hoffmann, Mathieu Gardeur, Idalie Sabah, Jonathan Kepka, Sabrina Bilbault, Pascal Lavoignet, Charles-Eric Vuillaume, Laure Abensur
Copyright Year	2022
Description	(1) Introduction: In the present study, we investigate the prognostic value of platelet-to-lymphocyte ratio (PLR) as a marker of severity and mortality in COVID-19 infection. (2) Methods: Between 1 March and 30 April 2020, we conducted a multicenter, retrospective cohort study of patients with moderate to severe coronavirus 19 (COVID-19), all of whom were hospitalized after being admitted to the emergency department (ED). (3) Results: A total of 1035 patients were included in our study. Neither lymphocytes, platelets or PLR were associated with disease severity. Lymphocyte count was significantly lower and PLR values were significantly higher in the group of patients who died, and both were associated with mortality in the univariate analysis (OR: 0.524, 95% CI: (0.336–0.815), p = 0.004) and (OR: 1.001, 95% CI: (1.000–1.001), p = 0.042), respectively. However, the only biological parameter significantly associated with mortality in the multivariate analysis was platelet count (OR: 0.996, 95% CI: (0.996–1.000), p = 0.027). The best PLR value for predicting mortality in COVID-19 was 356.6 (OR: 3.793, 95% CI: (1.946–7.394), p < 0.001). (4) Conclusion: A high PLR value is however associated with excess mortality.
Starting Page	4903
e-ISSN	20770383
DOI	10.3390/jcm11164903
Journal	Journal of clinical medicine
Issue Number	16
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2022-08-21
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Respiratory System Plr Platelet-to-lymphocyte Ratio Severity Mortality Covid-19
Content Type	Text
Resource Type	Article

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