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The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells
| Content Provider | MDPI |
|---|---|
| Author | Zhang, Linlin Qi, Jingyi Zhang, Xu Zhao, Xiya An, Peng Luo, Yongting Luo, Junjie |
| Copyright Year | 2022 |
| Description | Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. $Ca^{2+}$ is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. $Ca^{2+}$ participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of $Ca^{2+}$ through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of $Ca^{2+}$ in both mitochondria and cytoplasm, thereby regulating cellular $Ca^{2+}$ homeostasis. Mitochondrial $Ca^{2+}$ transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis. In particular, MCU and its regulatory proteins represent a new era in the study of MCU-mediated mitochondrial $Ca^{2+}$ homeostasis in tumors. Through an in-depth analysis of the close correlation between mitochondrial $Ca^{2+}$ and energy metabolism, autophagy, and apoptosis of tumor cells, we can provide a valuable reference for further understanding of how mitochondrial $Ca^{2+}$ regulation helps diagnosis and therapy. |
| Starting Page | 6667 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms23126667 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 12 |
| Volume Number | 23 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-06-15 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Mitochondrial Calcium Calcium Homeostasis Calcium Regulation Mcu Tumor |
| Content Type | Text |
| Resource Type | Article |
