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Mitochondrial calcium uniporter complex modulation in cancerogenesis
| Content Provider | Scilit |
|---|---|
| Author | Marchi, Saverio Vitto, Veronica Angela Maria Danese, Alberto Wieckowski, Mariusz Giorgi, Carlotta Pinton, Paolo |
| Copyright Year | 2019 |
| Description | Aberrations in mitochondrial $Ca^{2+}$ homeostasis have been associated with different pathological conditions, including neurological defects, cardiovascular diseases, and, in the last years, cancer. With the recent molecular identification of the mitochondrial calcium uniporter (MCU) complex, the channel that allows $Ca^{2+}$ accumulation into the mitochondrial matrix, alterations in the expression levels or functioning in one or more MCU complex members have been linked to different cancers and cancer-related phenotypes. In this review, we will analyze the role of the uniporter and mitochondrial $Ca^{2+}$ derangements in modulating cancer cell sensitivity to death, invasiveness, and migratory capacity, as well as cancer progression in vivo. We will also discuss some critical points and contradictory results to highlight the consequence of MCU complex modulation in tumor development. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592253/pdf |
| Ending Page | 1083 |
| Page Count | 16 |
| Starting Page | 1068 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.1080/15384101.2019.1612698 |
| Journal | Cell Cycle |
| Issue Number | 10 |
| Volume Number | 18 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-05-19 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Medical Laboratory Technology Mitochondria Calcium Cancer Mitochondrial Calcium Uniporter (mcu) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
