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Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug Release
| Content Provider | MDPI |
|---|---|
| Author | Benabbas, Rihab Sanchez-Ballester, Noelia Aubert, Adrien Sharkawi, Tahmer Bataille, Bernard Soulairol, Ian |
| Copyright Year | 2021 |
| Description | This study exposes the potential usefulness of a new co-processed excipient, composed of alginic acid and microcrystalline cellulose (Cop AA-MCC), for the preparation of immediate drug release tablets by direct compression. Evaluation of the physical and mechanical properties as well as the disintegration behavior of Cop AA-MCC in comparison to commercial co-processed excipients (Cellactose®, Ludipress®, Prosolv® SMCC HD90 and Prosolv® ODT) and to the physical mixture of the native excipients (MCC and AA), was carried out. The obtained results illustrate the good performance of Cop AA-MCC in terms of powder flowability, tablet tensile strength, compressibility, and disintegration time. Although, this new co-processed excipient showed a slightly high lubricant sensitivity, which was explained by its more plastic than fragmentary deformation behavior, it presented a low lubricant requirement due to the remarkably low ejection force observed during compression. Compression speed and dwell time seemed not to affect significantly the tabletability of Cop AA-MCC. The study exposed evenly the performance of Cop AA-MCC compared to Prosolv® ODT, in terms of tabletability and dissolution rate of Melatonin. Cop AA-MCC presented comparable hardness, lower dilution potential, higher lubricant sensitivity, lower ejection force, and faster Melatonin’s release time than Prosolv® ODT. In summary, Cop AA-MCC exhibited interesting physical, mechanical, and biopharmaceutical properties, which demonstrate its concurrence to commercially available co-processed excipients. Furthermore, the simplicity of its composition and the scalability of its elaboration makes this multifunctional excipient highly recommended for direct compression. |
| Starting Page | 988 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym13060988 |
| Journal | Polymers |
| Issue Number | 6 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-23 |
| Access Restriction | Open |
| Subject Keyword | Polymers Pharmacology and Pharmacy Co-processed Excipients Direct Compression Alginic Acid Melatonin |
| Content Type | Text |
| Resource Type | Article |
