NDLI: Investigation of Novel Multifunctional Co-Processed Excipient for Direct Compression

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Investigation of Novel Multifunctional Co-Processed Excipient for Direct Compression

Content Provider	Semantic Scholar
Author	Ambore, Sandeep M. Tekale, Jyoti
Copyright Year	2014
Abstract	The main purpose of the present Study was to develop novel multifunctional pharmaceutical excipient for direct compression. In the present study, novel multifunctional excipient were developed by Co-precipitation method using Dicalcium phosphate and carboxymethylcellulose sodium in different ratios (9.9:0.1, 9.8:0.2, 9.7:0.3, 9.6:0.4, 9.5:0.5 and 9.4:0.6) The developed excipients were evaluated for the micromeritic studies and bulk powder properties in comparison with physical mixture. It was observed that multifunctional co-processed Excipient exhibited much better flow properties as compared to physical mixture. The effect of addition of co-processed excipient in a formulation containing poorly compressible and high dose drug (paracetamol and ibuprofen), medium dose drug (Aceclofenac) and low dose drug (simvastatin) was also studied. The results of dilution potential study reveal that up to 50% Paracetamol and Ibuprofen a poorly compressible drug, can be incorporated in the multifunctional directly compressible excipient. Conventional tablets of paracetamol, ibuprofen, Aceclofenac and Simvastatin were prepared using the multifunctional directly compressible excipient and evaluated for post-compression parameters. From the present study It can be concluded that prepared multifunctional directly compressible excipient serve as 'ready-to-compress' powder mixtures for any kind of drugs.
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Alternate Webpage(s)	https://s9423e139345e2186.jimcontent.com/download/version/1431027268/module/9465429898/name/Investigation%20of%20Novel%20Multifunctiona%20Co-Process%20Excipient%20for%20Direct%20Compression.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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