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Engineering Biological Tissues from the Bottom-Up: Recent Advances and Future Prospects
| Content Provider | MDPI |
|---|---|
| Author | Wang, Xiaowen Wang, Zhen Zhai, Wenya Wang, Fengyun Ge, Zhixing Yu, Haibo Yang, Wenguang |
| Copyright Year | 2021 |
| Description | Tissue engineering provides a powerful solution for current organ shortages, and researchers have cultured blood vessels, heart tissues, and bone tissues in vitro. However, traditional top-down tissue engineering has suffered two challenges: vascularization and reconfigurability of functional units. With the continuous development of micro-nano technology and biomaterial technology, bottom-up tissue engineering as a promising approach for organ and tissue modular reconstruction has gradually developed. In this article, relevant advances in living blocks fabrication and assembly techniques for creation of higher-order bioarchitectures are described. After a critical overview of this technology, a discussion of practical challenges is provided, and future development prospects are proposed. |
| Starting Page | 75 |
| e-ISSN | 2072666X |
| DOI | 10.3390/mi13010075 |
| Journal | Micromachines |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-31 |
| Access Restriction | Open |
| Subject Keyword | Micromachines Bottom-up Tissue Engineering Drug Screening Modular Assembly Micro-fabrication |
| Content Type | Text |
| Resource Type | Article |
