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Soft Matter Vol - 5 Issue - 6

Soft Matter Vol - 5 Issue - 5

Soft Matter Vol - 5 Issue - 4

Soft Matter Vol - 5 Issue - 3

Modular tissue engineering: engineering biological tissues from the bottom up

Content Provider	Royal Society of Chemistry (RSC)
Author	Nichol, Jason W. Khademhosseini, Ali
Copyright Year	2009
Abstract	Tissue engineering creates biological tissues that aim to improve the function of diseased or damaged tissues. To enhance the function of engineered tissues there is a need to generate structures that mimic the intricate architecture and complexity of native organs and tissues. With the desire to create more complex tissues with features such as developed and functional microvasculature, cell binding motifs and tissue specific morphology, tissue engineering techniques are beginning to focus on building modular microtissues with repeated functional units. The emerging field known as modular tissue engineering focuses on fabricating tissue building blocks with specific microarchitectural features and using these modular units to engineer biological tissues from the bottom up. In this review we will examine the promise and shortcomings of “bottom-up” approaches to creating engineered biological tissues. Specifically, we will survey the current techniques for controlling cell aggregation, proliferation and extracellular matrix deposition, as well as approaches to generating shape-controlled tissue modules. We will then highlight techniques utilized to create macroscale engineered biological tissues from modular microscale units.
Starting Page	1312
Ending Page	1319
Page Count	8
File Format	HTM / HTML PDF
ISSN	1744683X
Volume Number	5
Issue Number	7
Journal	Soft Matter
DOI	10.1039/b814285h
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Tissue engineering Extracellular matrix
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics

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Modular Tissue Engineering: Engineering Biological Tissues from the Bottom Up

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A Paradigm Shift in Tissue Engineering: From a Top–Down to a Bottom–Up Strategy

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OF THE EXTRACELLULAR MATRIX OF DENTAL TISSUES

Modular tissue engineering: engineering biological tissues from the bottom up

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Modular tissue engineering: engineering biological tissues from the bottom up