NDLI: Aptamer-Modified Semiconductor Quantum Dots for Biosensing Applications

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Aptamer-Modified Semiconductor Quantum Dots for Biosensing Applications

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Aptamer-Modified Semiconductor Quantum Dots for Biosensing Applications

Content Provider	MDPI
Author	Wen, Lin Qiu, Liping Wu, Yongxiang Hu, Xiaoxiao Zhang, Xiaobing
Abstract	Semiconductor quantum dots have attracted extensive interest in the biosensing area because of their properties, such as narrow and symmetric emission with tunable colors, high quantum yield, high stability and controllable morphology. The introduction of various reactive functional groups on the surface of semiconductor quantum dots allows one to conjugate a spectrum of ligands, antibodies, peptides, or nucleic acids for broader and smarter applications. Among these ligands, aptamers exhibit many advantages including small size, high chemical stability, simple synthesis with high batch-to-batch consistency and convenient modification. More importantly, it is easy to introduce nucleic acid amplification strategies and/or nanomaterials to improve the sensitivity of aptamer-based sensing systems. Therefore, the combination of semiconductor quantum dots and aptamers brings more opportunities in bioanalysis. Here we summarize recent advances on aptamer-functionalized semiconductor quantum dots in biosensing applications. Firstly, we discuss the properties and structure of semiconductor quantum dots and aptamers. Then, the applications of biosensors based on aptamer-modified semiconductor quantum dots by different signal transducing mechanisms, including optical, electrochemical and electrogenerated chemiluminescence approaches, is discussed. Finally, our perspectives on the challenges and opportunities in this promising field are provided.
File Size	2727936
File Format	PDF
e-ISSN	14248220
DOI	10.3390/s17081736
Journal	Sensors
Issue Number	8
Volume Number	17
Language	English
Publisher Date	2017-07-28
Access Restriction	Open
Subject Keyword	semiconductor quantum dots aptamer biosensors
Content Type	Text
Resource Type	Article

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